Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Bioassay-guided isolation of cytotoxic compounds from Chrysophthalmum montanum (DC.) Boiss
Food and Chemical Toxicology · Mart 2019
YÖKSİS Kayıtları
Bioassay-guided isolation of cytotoxic compounds from Chrysophthalmum montanum (DC.) Boiss.
Food and Chemical Toxicology · 2019 SCI-Expanded
Doç. Dr. FATMA AYAZ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI 15 atıf
Prof. Dr. GÖKHAN ZENGİN →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI 12 atıf
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L species
2013 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L species from Turkey flora
2011 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
In vitro antioxidant capacities and fatty acid compositions of three Centaurea species collected from Central Anatolia region of Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Organochlorine pesticide residues in wheat from Konya region Turkey
2010 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SCI-Expanded
Öğr. Gör. NESİM DURSUN →
Mineral and heavy metal levels of some fruits grown at the roadsides
2010 ISSN: 0278-6915 SSCI 23 atıf
Prof. Dr. SAİT GEZGİN →
Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L dill samples cultivated under organic and conventional agricultural conditions
2013 ISSN: 0278-6915 SCI-Expanded Q1
Dr. Öğr. Üyesi SADİYE AYŞE ÇELİK →
Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents
2018 ISSN: 0278-6915 SCI
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Bioactivities of Achillea phrygia and Bupleurum croceum based on the composition of phenolic compounds: In vitro and in silico approaches
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Evaluation of antioxidant potential, enzyme inhibition activity and phenolic profile of Lathyrus cicera and Lathyrus digitatus : Potential sources of bioactive compounds for the food industry
2017 ISSN: 02786915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Combining in vitro , in vivo and in silico approaches to evaluate nutraceutical potentials and chemical fingerprints of Moltkia aurea and Moltkia coerulea
2017 ISSN: 02786915 SCI
Prof. Dr. GÖKHAN ZENGİN →
UHPLC-QTOF-MS analysis of bioactive constituents from two Romanian Goji (Lycium barbarum L.) berries cultivars and their antioxidant, enzyme inhibitory, and real-time cytotoxicological evaluation
2018 ISSN: 0278-6915 SCI
Prof. Dr. GÖKHAN ZENGİN →
Investigations into the therapeutic potential of Asphodeline liburnica roots: In vitro and in silico biochemical and toxicological perspectives
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Novel in vitro and in silico insights of the multi-biological activities and chemical composition of Bidens tripartita L.
2018 ISSN: 0278-6915 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN02786915
Yayın TarihiMart 2019
Cilt / Sayfa125 · 10-20
Scopus ID2-s2.0-85059058009
Özet
Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6α-acetoxy-4α-hydroxy-1βH-guaia-9.11(13)-dien-12.8α-olide (1), 6α-acetoxy-4α-hydroxy-9β.10β-epoxy-1βH-guaia-11(13)-en-12.8α-olide (2), 4α,6α-dihydroxy-1β,5α,7αH-guaia-9(10),11(13)-dien-12,8α-olide (3), and (4α,5α,8β,10β)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4), along a steroidal glycoside mixture (5a and 5b). The structures of the compounds were identified on the basis of spectroscopic data. Among them, 2, 4 and a steroidal glycoside mixture were obtained from C. montanum for the first time. All isolates were also first time assayed for in vitro cytotoxicities against four human cancer cell lines, i.e. breast (MCF-7, MDA-MB 231), colon (HT-29), and lung (PC3). Among the isolates, 1–3 showed significant inhibitory effect on the proliferation of cancer cells with viability ranging from 6.86 to 26.51%, while steroidal glycoside mixture showed no cytotoxicity, except against HT-29 (viability 61.99%). Compound 4 exhibited strong and selective cell growth inhibition against HT-29 with viability 20.99% and was identified as a promising compound with high selectivity between cancer cells and normal human lung cells (BEAS-2B), especially against HT-29 (IC 50 = 12.2 μg/mL) compared to that of cisplatin. These results suggested that 4 is worthy of further study to determine its cytotoxicity mechanisms.
Yazarlar (8)
1
Fatma Ayaz
2
Nurgün Küçükboyacı
3
Nezhun Gören
4
İhsan Çalış
5
Şeyma Aydınlık
6
Engin Ulukaya
7
Hayri Duman
8
M. Iqbal Choudhary
Anahtar Kelimeler
Asteraceae
Chrysophthalmum montanum
Cytotoxicity
HT-29 colon cancer cell line
Sesquiterpene lactones
Steroidal glycosides
Kurumlar
Bursa Uludağ Üniversitesi
Bursa Turkey
Gazi Üniversitesi
Ankara Turkey
İstinye Üniversitesi
Istanbul Turkey
King Abdulaziz University
Jeddah Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
University of Karachi
Karachi Pakistan
Yakın Doğu Üniversitesi
Nicosia Cyprus
Yıldız Teknik Üniversitesi
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Food and Chemical Toxicology
Q1
SJR Skoru0,750
H-Index223
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Medicine (miscellaneous) (Q2)
Toxicology (Q2)
Metrikler
5
Atıf
8
Yazar
6
Anahtar Kelime