Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Anti-inflammatory activity of sesquiterpene lactones from chrysophthalmum montanum (DC.) boiss
Records of Natural Products · Ocak 2020
YÖKSİS Kayıtları
Anti-inflammatory Activity of Sesquiterpene Lactones from Chrysophthalmum montanum (DC.) Boiss.
Records of Natural Products · 2020 SCI-Expanded
Doç. Dr. FATMA AYAZ →
Makale Bilgileri
Dergi
Records of Natural Products
Yayın TarihiOcak 2020
Cilt / Sayfa14 · 48-56
Scopus ID2-s2.0-85073540535
Erişim🔓 Açık Erişim
Özet
The aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) is traditionally used for wound healing, as well as for the treatment of common cold, sinusitis, and other inflammatory diseases. The objectives of this study were to identify potential anti-inflammatory effects of the methanol extract, and its different polarity subextracts (n-hexane, chloroform, n-butanol, and remaining aqueous), and guaianolide-type sesquiterpene lactones [6α-acetoxy-4α-hydroxy-1βH-guaia-9.11(13)-dien-12.8α-olide (1), 6α-acetoxy-4α-hydroxy-9β.10β-epoxy-1βH-guaia-11(13)-en-12.8α-olide (2), 4α,6α-dihydroxy-1β,5α,7αH-guaia-9(10),11(13)-dien-12,8α-olide (3), and (4α,5α,8β,10β)-4,10-dihydroxy-1,11(13)-guaidien-12,8-olide (4)] from the aerial parts of C. montanum. In order to evaluate the anti-inflammatory activity of C. montanum, carrageenan-and PGE2-induced hind paw edema, and acetic acid-induced increase in capillary permeability mice models were used. The methanol extract, the chloroform subextract, and compounds 3, and 4 were shown to possess anti-inflammatory activity in in vivo models at 100 mg/kg dose. The results provide a biological, and phytochemical basis for the traditional use of C. montanum aerial parts for inflammatory conditions in Turkish folk medicine.
Yazarlar (8)
1
Fatma Ayaz
2
Esra Küpeli
3
Nezhun Gören
4
İhsan Çalış
5
F. Tuğçe Gürağaç Dereli
ORCID: 0000-0002-7554-733X
6
Hayri Duman
7
M. Iqbal Choudhary
8
Nurgün Küçükboyacı
Anahtar Kelimeler
Anti-inflammatory
Asteraceae
Carrageenan
Chrysophthalmum montanum
Prostaglandins
Sesquiterpene lactones
Kurumlar
Gazi Üniversitesi
Ankara Turkey
King Abdulaziz University
Jeddah Saudi Arabia
Selçuk Üniversitesi
Selçuklu Turkey
University of Karachi
Karachi Pakistan
Yakın Doğu Üniversitesi
Nicosia Cyprus
Yeni Yüzyıl Üniversitesi
Istanbul Turkey
Metrikler
1
Atıf
8
Yazar
6
Anahtar Kelime