Scopus
YÖKSİS Eşleşti
Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach
Current Topics in Medicinal Chemistry · Ocak 2024
YÖKSİS Kayıtları
Immunomodulatory Effect of Phytoactive Compounds on Human Health: A Narrative Review Integrated with Bioinformatics Approach
Current Topics in Medicinal Chemistry · 2024 SCI-Expanded
PROFESÖR SAİT GEZGİN →
Immunomodulatory Effect of Phytoactive Compounds on Human Health:
A Narrative Review Integrated with Bioinformatics Approach
Current Topics in Medicinal Chemistry · 2024 SCI-Expanded
PROFESÖR SAİT GEZGİN →
Immunomodulatory Effect of Phytoactive Compounds on Human Health:
A Narrative Review Integrated with Bioinformatics Approach
Current Topics in Medicinal Chemistry · 2024 SCI-Expanded
PROFESÖR MEHMET HAMURCU →
Makale Bilgileri
DergiCurrent Topics in Medicinal Chemistry
Yayın TarihiOcak 2024
Cilt / Sayfa24 · 1075-1100
Scopus ID2-s2.0-85195630613
Özet
Background: Immunomodulation is the modification of immune responses to control disease progression. While the synthetic immunomodulators have proven efficacy, they are coupled with toxicity and other adverse effects, and hence, the efforts were to identify natural phytochemicals with immunomodulatory potential. Objective: To understand the immunomodulatory properties of various phytochemicals and investigate them in Echinacea species extracts using an in silico approach. Methodology: Several scientific database repositories were searched using different keywords: “Phytochemicals,” “Alkaloids,” “Polyphenols,” “Flavonoids,” “Lectins,” “Glycosides,” “Tannins,” “Terpenoids,” “Sterols,” “Immunomodulators,” and “Human Immune System” without any language restriction. Additionally, the study specifically investigated the immunomodulatory properties of Echinacea species extracts using gene expression analysis of GSE12259 from NCBI-GEO through the Bioconductor package GEOquery and limma. Results: A total of 182 studies were comprehensively analyzed to understand immunomodulatory phytochemicals. The in silico analysis highlighted key biological processes (positive regulation of cytokine production, response to tumor necrosis factor) and molecular functions (cytokine receptor binding, receptor-ligand activity, and cytokine activity) among Echinacea species extracts contributing to immune responses. Further, it also indicated the association of various metabolic pathways, i.e., pathways in cancer, cytokine-cytokine receptor interaction, NF-kappa B, PI3K-Akt, TNF, MAPK, and NOD-like receptor signaling pathways, with immune responses. The study revealed various hub targets, including CCL20, CCL4, GCH1, SLC7A11, SOD2, EPB41L3, TNFAIP6, GCLM, EGR1, and FOS. Conclusion: The present study presents a cumulative picture of phytochemicals with therapeutic benefits. Additionally, the study also reported a few novel genes and pathways in Echinacea extracts by re-analyzing GSE 12259 indicating its anti-inflammatory, anti-viral, and immunomodulatory properties.
Yazarlar (12)
1
Saumya Choudhary
2
Sheeba Khan
3
Shivani Rustagi
4
Vijay Rani Rajpal
5
Noor Saba Khan
6
Neeraj Kumar
7
George Thomas
8
Anamika Pandey
ORCID: 0000-0002-5022-8359
9
M. Hamurcu
10
Sait Gezgin
ORCID: 0000-0002-3795-4575
11
Sajad Majeed Zargar
12
Mohd Kamran Khan
Anahtar Kelimeler
Bioactive compounds
Differential gene expression
Echinacea species
Immunomodulatory
Metabolic pathways
Phytochemicals
Kurumlar
Gautam Buddha University
Greater Noida India
Hansraj College
New Delhi India
National Institute of Pathology
New Delhi India
Sam Higginbottom University of Agriculture, Technology and Sciences
Prayagraj India
Selçuk Üniversitesi
Selçuklu Turkey
Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir
Srinagar India
Metrikler
1
Atıf
12
Yazar
6
Anahtar Kelime