Scopus
YÖKSİS Eşleşti
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · Ocak 2020
YÖKSİS Kayıtları
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
DOÇENT ÇAĞDAŞ ELSÜRER →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2018 SCI-Expanded
PROFESÖR ÖMER ERDUR →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
DOÇENT MERİH ÖNAL →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
POSTCONDITIONING OZONE ALLEVIATES ISCHEMIA-REPERFUSION INJURY AND ENHANCES FLAP ENDURANCE IN RATS
JOURNAL OF INVESTIGATIVE SURGERY · 2018 SCI-Expanded
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
PROFESÖR JALE BENGİ ÇELİK →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
PROFESÖR ÖMER ERDUR →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
PROFESÖR ENDER ERDOĞAN →
Postconditioning Ozone Alleviates Ischemia-Reperfusion Injury and Enhances Flap Endurance in Rats
Journal of Investigative Surgery · 2020 SCI-Expanded
PROFESÖR ENDER ERDOĞAN →
Makale Bilgileri
DergiJournal of Investigative Surgery
Yayın TarihiOcak 2020
Cilt / Sayfa33 · 15-24
Scopus ID2-s2.0-85055354082
Özet
Introduction: Muscle-flap transferring is a routine approach utilized in reconstructive operations; however, flap morbidity is often a source of post-operative difficulty. Ischemia-Reperfusion Injury (IRI) is an important contributor to the viability of flaps after transferring. The goal of this research was for assess the probable useful impacts of ozone on flap survival in a rat muscle-flap design. Materials and Methods: We examined the effects of postconditioning ozone administration on viability of pedicled composite flaps. Twenty-eight Wistar rats were randomized into four groups: sham-operated (S), ischemia-reperfusion (IR), sham-operated + ozone (O), IR + ozone (IR + O), respectively. The animals were sacrificed on the eighth day. In a general histological evaluation, flap tissues were examined with a light microscope, and apoptotic cells were counted. The Apoptotic Index (AI) was then calculated. Flap-tissue samples were sent for analyses of malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and protein carbonyl (PCO), and blood samples were sent for analyses of Total Oxidant Score (TOS), and Total Antioxidant Capacity (TAC). Data were evaluated statistically using the Kruskal–Wallis test. Results: The histomorphometric score was remarkably greater in O (p =.002). The AI was greater in IR (p =.002). The antioxidant parameters values as regards SOD, GSH-Px, CAT, and TAC were found to be greater in O (p <.005). The oxidant parameters values as regards MDA, PCO, TOS were found to be greater in IR (p <.005). Discussion: The current research indicates that ozone application can attenuate the muscle-flap injury brought about by IR through triggering the increase of the antioxidant capacity.
Yazarlar (9)
1
Çağdaş Elsürer
ORCID: 0000-0001-9804-7023
2
Merih Onal
ORCID: 0000-0003-0591-8411
3
Nebil Selimoglu
4
O. Erdur
5
Mustafa Yilmaz
6
Ender Erdoğan
7
Oznur Kal
8
Jale Çelik
9
Ozkan Onal
ORCID: 0000-0002-5574-1901
Anahtar Kelimeler
antioxidant
apoptosis
ischemia reperfusion injury
ozone
surgical flaps
Kurumlar
Başkent Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
9
Yazar
5
Anahtar Kelime