Scopus
YÖKSİS Eşleşti
Synthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug release
Materials Science and Engineering: B · Ocak 2024
YÖKSİS Kayıtları
Synthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug release
Materials Science and Engineering: B · 2024 SCI-Expanded
PROFESÖR ESRA MALTAŞ ÇAĞIL →
Synthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug release
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS · 2024 SCI-Expanded
PROFESÖR ESRA MALTAŞ ÇAĞIL →
Synthesis and characterization of new targeted pH-responsive heteroatom-doped hexagonal boron nitride nanosheets for controlled drug release
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ KÜBRA YILMAZ →
Makale Bilgileri
DergiMaterials Science and Engineering: B
Yayın TarihiOcak 2024
Cilt / Sayfa299
Scopus ID2-s2.0-85173580620
Özet
In this study, sulfur doped hexagonal boron nitride (S-h-BN) and fluorine doped hexagonal boron nitride (F-h-BN) were prepared via the exfoliation and heat treatment of bulk boron nitride (B-BN). Then, Human Serum Albumin (HSA) were immobilized onto the obtained hexagonal boron nitride nanolayer (NLs) surfaces to enhance irinotecan loading, which is a fluorescent molecule having excitation and emission at the wavelengths of 299 nm and 436 nm, respectively. The loading and release properties were studied at different pH values. Whereas the maximum loading amounts were achieved at the pH of 4.0 for all nanosheets, the pH value at which the maximum drug release was observed were found to be different for all samples. The physicochemical characterization of the nanosheets were conducted by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared (FTIR) spectroscopy methods. The XRD and FTIR results indicated the successful synthesis of h-BN and the 2D structure of the nanolayers were imaged using SEM and TEM methods. The F and S content inserted into the h-BN structure was determined to be about 2.45 and 0.1 at. % using the XPS method. In addition, the bonding structre of the modified h-BN monolayers were unraveled by the deconvulation of the XPS results.
Yazarlar (5)
1
Havva Nur Gurbuz
2
Kubra Yilmaz
3
Hasan H. Ipekci
4
Aytekin Uzunoglu
5
Esra Maltas Cagil
Anahtar Kelimeler
Albumin
Controlled drug delivery
Drug delivery
Hexagonal boron nitride
Pharmaceuticals
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
5
Yazar
5
Anahtar Kelime