Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Milk and blood pharmacokinetics of Tylosin and Tilmicosin following parenteral administrations to cows
Scientific World Journal · Ocak 2014
YÖKSİS Kayıtları
Milk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cows
The Scientific World Journal · 2014 SCI-Expanded
Prof. Dr. MUAMMER ELMAS →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Effectiveness of Anti R equi Hyperimmune Plasma against R equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R equi Vaccine
2014 ISSN: 2356-6140 SCI-Expanded 2 atıf
Prof. Dr. ÖZGÜR ÖZDEMİR →
On the Number of Spanning Trees of Graphs
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. ŞERİFE BURCU BOZKURT ALTINDAĞ →
Comparison of the Chromosome Banding Pattern in the 2n 56 Cytotypes of Nannospalax leucodon and N xanthodon from Turkey
2014 ISSN: 2356-6140 SCI-Expanded 5 atıf
Prof. Dr. ATİLLA ARSLAN →
Residual HEMA and TEGDMA Release and Cytotoxicity Evaluation of Resin Modified Glass Ionomer Cement and Compomers Cured with Different Light Sources
2014 ISSN: 2356-6140 EBSCO
Prof. Dr. MURAT SELİM BOTSALI →
Residual HEMA and TEGDMA Release and Cytotoxicity Evaluation of Resin Modified Glass Ionomer Cement and Compomers Cured with Different Light Sources
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. HAYRİYE ESRA ÜLKER →
Morphological Characteristics of Renal Artery and Kidney in Rats
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. MUSTAFA ORHUN DAYAN →
Fatty Acid Composition and Conjugated Linoleic Acid Content in Different Carcass parts of Dağlıç Lambs
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. SAİM BOZTEPE →
Residual HEMA and TEGDMA Release and Cytotoxicity Evaluation of Resin Modified Glass Ionomer Cement and Compomers Cured with Different Light Sources
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. MURAT SELİM BOTSALI →
Milk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cows
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. MUAMMER ELMAS →
The Effectiveness of Anti R equi Hyperimmune Plasma against R equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R equi Vaccine
2014 ISSN: 2356-6140 SCI-Expanded 1 atıf
Prof. Dr. ZAFER SAYIN →
The Effect of Prophylactic Polishing Pastes on Surface Roughness of Indirect Restorative Materials
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. NİMET ÜNLÜ →
The Segmental Morphometric Properties of the Horse Cervical Spinal Cord: A Study of Cadaver
2013 ISSN: 2356-6140 SCI-Expanded Q2
Prof. Dr. SADULLAH BAHAR →
The Effectiveness of Anti-R. equi Hyperimmune Plasma againstR. equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R. equi Vaccine
2014 ISSN: 2356-6140 SCI
Dr. Öğr. Üyesi YASEMİN KARYEYEN →
The Effectiveness of Anti-R. equi Hyperimmune Plasma against R. equi Challenge in Thoroughbred Arabian Foals of Mares Vaccinated with R-equi Vaccine
2014 ISSN: 2356-6140 SCI-Expanded
Prof. Dr. MEHMET MADEN →
Makale Bilgileri
Dergi
Scientific World Journal
ISSN23566140
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84929940078
Erişim🔓 Açık Erişim
Özet
The aim of this study is to determine the pharmacokinetics of tylosin and tilmicosin in serum and milk in healthy Holstein breed cows (n = 12) and reevaluate the amount of residue in milk. Following the intramuscular administration of tylosin, the maximum concentrations (C max) in serum and milk were found to be 1.30 ± 0.24 and 4.55 ± 0.23 μg/mL, the time required to reach the peak concentration (t max) was found to be 2nd and 4th h, and elimination half-lives (t 1 / 2 β) were found to be 20.46 ± 2.08 and 26.36 ± 5.55 h, respectively. Following the subcutaneous administration of tilmicosin, the C max in serum and milk were found to be 0.86 ± 0.20 and 20.16 ± 1.13 μg/mL, the t max was found to be 1st and 8th h, and the t 1 / 2 β were found to be 29.94 ± 6.65 and 43.02 ± 5.18 h, respectively. AU C milk / AU C serum and C max-milk / C max-serum rates, which are indicators for determining the rate of drugs that pass into milk, were, respectively, calculated as 5.01 ± 0.72 and 3.61 ± 0.69 for tylosin and 23.91 ± 6.38 and 20.16 ± 1.13 for tilmicosin. In conclusion, it may be stated that milk concentration of tylosin after parenteral administration is higher than expected like tilmicosin and needs more withdrawal period for milk than reported.
Yazarlar (2)
1
Tülay Avci
2
M. Elmas
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Veterinary Control and Research Institute
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Scientific World Journal
Q2
OA
SJR Skoru0,661
H-Index146
YayıncıJohn Wiley and Sons Ltd
ÜlkeUnited Kingdom
Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q2)
Environmental Science (miscellaneous) (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
30
Atıf
2
Yazar