Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Milk and blood pharmacokinetics of Tylosin and Tilmicosin following parenteral administrations to cows
Scientific World Journal · Ocak 2014
YÖKSİS Kayıtları
Milk and Blood Pharmacokinetics of Tylosin and Tilmicosin following Parenteral Administrations to Cows
The Scientific World Journal · 2014 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Makale Bilgileri
DergiScientific World Journal
Yayın TarihiOcak 2014
Cilt / Sayfa2014
Scopus ID2-s2.0-84929940078
Erişim🔓 Açık Erişim
Özet
The aim of this study is to determine the pharmacokinetics of tylosin and tilmicosin in serum and milk in healthy Holstein breed cows (n = 12) and reevaluate the amount of residue in milk. Following the intramuscular administration of tylosin, the maximum concentrations (C max) in serum and milk were found to be 1.30 ± 0.24 and 4.55 ± 0.23 μg/mL, the time required to reach the peak concentration (t max) was found to be 2nd and 4th h, and elimination half-lives (t 1 / 2 β) were found to be 20.46 ± 2.08 and 26.36 ± 5.55 h, respectively. Following the subcutaneous administration of tilmicosin, the C max in serum and milk were found to be 0.86 ± 0.20 and 20.16 ± 1.13 μg/mL, the t max was found to be 1st and 8th h, and the t 1 / 2 β were found to be 29.94 ± 6.65 and 43.02 ± 5.18 h, respectively. AU C milk / AU C serum and C max-milk / C max-serum rates, which are indicators for determining the rate of drugs that pass into milk, were, respectively, calculated as 5.01 ± 0.72 and 3.61 ± 0.69 for tylosin and 23.91 ± 6.38 and 20.16 ± 1.13 for tilmicosin. In conclusion, it may be stated that milk concentration of tylosin after parenteral administration is higher than expected like tilmicosin and needs more withdrawal period for milk than reported.
Yazarlar (2)
1
Tülay Avci
2
M. Elmas
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Veterinary Control and Research Institute
Konya Turkey
Metrikler
25
Atıf
2
Yazar