Scopus
YÖKSİS Eşleşti
The embryotoxic and teratogenic effects of metamizole sodium
Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia · Eylül 2024
YÖKSİS Kayıtları
The embryotoxic and teratogenic effects of metamizole sodium
Anatomia, Histologia, Embryologia · 2024 SCI-Expanded
PROFESÖR MUSTAFA ORHUN DAYAN →
Makale Bilgileri
DergiJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologia
Yayın TarihiEylül 2024
Cilt / Sayfa53
Scopus ID2-s2.0-85201066483
Özet
Drug use during pregnancy is an important issue that must be investigated due to its adverse effects on maternal and foetal health. This study aimed to determine the embryotoxic and teratogenic effects of in-ovo administered metamizole (dipyrone), which can be used when needed during pregnancy and has potent analgesic, antipyretic, anti-inflammatory, and long bone (tibia and femur) effects. This study used 240 fertile eggs from Atak S breed chickens, divided into eight equal groups: control, vehicle control, and 15.62, 31.25, 62.5, 125, 250 and 500 mg/kg metamizole. The eggs were hatched on the 21st day of incubation, and the chicks' body weights and mortality rates were determined. The right and left femur and tibia bones were resected from the chicks. Anatomical reference points were determined after removing the soft tissues of the bones, and necessary morphometric measures were taken from these points with a 0.01 mm precision using digital callipers. The 100% lethal dose (LD100) was identified in the highest examined dose (500 mg/kg) in the Chicken Embryotoxicity Screening Test (CHEST)-I stage. The CHEST-II stage determined the 50% lethal dose (LD50). High-dose metamizole affected skeletal development, significantly decreasing tibia and femur lengths and corpus thicknesses and increasing mortality.
Yazarlar (2)
1
Selvinaz Öztürk
ORCID: 0000-0001-8184-6849
2
M. O. Dayan
Anahtar Kelimeler
chicken embryo
embryotoxicity
LD 50
metamizole
teratogenicity
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey