Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis
Polish Journal of Veterinary Sciences · Ocak 2020
YÖKSİS Kayıtları
Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis
Polish Journal of Veterinary Sciences · 2020 SCI-Expanded
PROFESÖR MAHMUT OK →
Assessment of intestinal and cardiac-relatedbiomarkers in dogs with parvoviral enteritis
Polish Journal of Veterinary Sciences · 2020 SCI-Expanded
PROFESÖR MUTLU SEVİNÇ →
Assessment of intestinal and cardiac-related biomarkers in dogs with parvoviral enteritis
Polish Journal of Veterinary Sciences · 2020 SCI-Expanded
DOÇENT MERVE İDER →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2020
Cilt / Sayfa23 · 211-219
Scopus ID2-s2.0-85087473879
Erişim🔓 Açık Erişim
Özet
The aim of this study was to evaluate the intestinal and cardiac biomarkers in the determination of intestinal and cardiac damage in dogs with parvoviral enteritis. The material of this study consisted of 10 healthy dogs (control group) and 30 dogs with parvoviral enteritis (experimental group) admitted to the Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University. Serum samples were extracted from the collected blood samples taken from vena cephalica venipuncture for analysis of blood gases, haemogram and to measure the levels of intestinal-fatty acid-binding protein (I-FABP), trefoil factor 3 (TFF-3), claudin-3 (CLDN-3), heart-type fatty acid-binding protein (H-FABP), cardiac troponin I (cTnI), and creatine kinase-myocardial band (CK-MB) by enzyme linked immunosorbent assay (ELISA) test kits. Statistically significant decreases in the blood gas hydrogen ion concentration (pH), partial pressure of oxygen (pO2), sodium (Na), bicarbonate (HCO3), and oxygen saturation (SatO2) levels and significant increase in the levels of I-FABP, TFF-3, CK-MB, cTnI and also in the haemogram, a decrease in leukocyte (WBC) level and an increase in platelet (THR) level were detected in parvoviral dogs compared to the control group (p<0.05). Also ROC analysis revealed on 0th hour for the utility of I-FABP and on 48th hour for TFF-3 in differentiating in the experimental group between the survivor and non-survivor dogs. Other intestinal-related biomarker (CLDN-3) and none of the cardiac-related biomarkers (H-FABP, CK-MB and cTnI) are not high enough for prediction of mortality. In conclusion, it was determined that I-FABP and TFF-3 for the intestinal injury and mortality prediction, and CK-MB and cTnI for the cardiac injury were useful and reliable biomarkers to determine the damage caused by parvovirus in dogs.
Yazarlar (7)
1
Erdem Gülersoy
ORCID: 0000-0001-8511-0150
2
M. Ok
3
Ramazan Yildiz
4
Erman Koral
5
Merve Ider
ORCID: 0000-0003-2928-5452
6
Mutlu Sevinc
7
A. Zhunushova
Anahtar Kelimeler
Biomarkers
Cardiac biomarkers
Dog
Intestinal biomarkers
Parvoviral enteritis
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
7
Yazar
5
Anahtar Kelime