Scopus
YÖKSİS Eşleşti
Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep
Acta Veterinaria Hungarica · Mart 2020
YÖKSİS Kayıtları
Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep
Acta Veterinaria Hungarica · 2020 SCI-Expanded
DOÇENT MERVE İDER →
Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep
Acta Veterinaria Hungarica · 2020 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiActa Veterinaria Hungarica
Yayın TarihiMart 2020
Cilt / Sayfa68 · 65-70
Scopus ID2-s2.0-85086513933
Özet
The pharmacokinetics of levofloxacin (4 mg/kg), administered both alone and in combination with tolfenamic acid (2 mg/kg) and flunixin meglumine (2.2 mg/kg), was established after intravenous administration in sheep. Plasma levofloxacin concentrations were assayed by high-performance liquid chromatography and analysed according to the two-compartment open model. Following the administration of levofloxacin alone, the mean distribution half-life, elimination half-life, total clearance, volume of distribution at steady state and area under the plasma concentration-time curve were 0.20 h, 1.82 h, 0.39 L/h/kg, 0.96 L/kg and 10.40 h 3 mg/mL, respectively. Tolfenamic acid and flunixin meglumine caused a slow elimination and increased plasma concentrations of levofloxacin in combination administration. Levofloxacin, with an alteration in the dosage regimen, can be used effectively with tolfenamic acid and flunixin meglumine for the therapy of infections and inflammatory conditions in sheep.
Yazarlar (7)
1
D. Durna Corum
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
Ramazan Yildiz
4
Hatice Eser Faki
5
Merve Ider
ORCID: 0000-0003-2928-5452
6
Gul Cetin
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Flunixin meglumine
Levofloxacin
Pharmacokinetics
Sheep
Tolfenamic acid
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
7
Yazar
5
Anahtar Kelime