Scopus
YÖKSİS Eşleşti
Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep
Journal of Veterinary Pharmacology and Therapeutics · Eylül 2022
YÖKSİS Kayıtları
Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI
PROFESÖR MAHMUT OK →
Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2022 SCI-Expanded
DOÇENT MERVE İDER →
Pharmacokinetics of carprofen following single and repeated intravenous administrations of different doses in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiEylül 2022
Cilt / Sayfa45 · 481-487
Scopus ID2-s2.0-85132550987
Özet
The aim of this study was to determine the pharmacokinetics of carprofen following single and repeated intravenous (IV) administrations at 1.4 and 4 mg/kg doses in sheep. The study was carried out on twelve sheep in two experiments as single- and multiple-dose pharmacokinetics. In experiment 1, carprofen was administered via IV at single doses of 1.4 (n = 6) and 4 mg/kg (n = 6) in a randomized parallel design. In experiment 2, the same dose groups in experiment 1 following the 21-day washout period received intravenously carprofen every 24 h for 5 days. Plasma concentrations were measured using high-performance liquid chromatography–UV and analyzed by a two-compartment open model. After the single administration of 1.4 mg/kg dose, the t1/2α, t1/2el, MRT, ClT, Vdss, and AUC were 0.62 h, 27.57 h, 38.78 h, 2.72 ml/h/kg, 105.26 ml/kg, and 515.12 h*μg/ml, respectively. Carprofen at a single dose of 4 mg/kg showed prolonged t1/2el and MRT, and increased Vdss. On day 5 after the repeated administration of the 1.4 mg/kg dose, the t1/2α, t1/2el, MRT, ClT, Vdss, and AUC were 1.12 h, 57.48 h, 82.18 h, 0.55 ml/h/kg, 45.43 ml/kg, and 2532 h*μg/ml, respectively. Carprofen at a repeated dose of 4 mg/kg showed increased ClT and Vdss and decreased AUC/dose. Although the long t1/2ʎz in single and multiple IV dose studies suggest the possibility of its effective use, the IV route may not be practical in sheep. Therefore, oral and subcutaneous routes of carprofen in sheep would be more valuable in clinical settings.
Yazarlar (7)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Devran Coskun
ORCID: 0000-0003-1151-1861
3
D. Durna Corum
4
Merve Ider
ORCID: 0000-0003-2928-5452
5
Ramazan Yildiz
6
M. Ok
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
carprofen
intravenous
multiple doses
pharmacokinetics
sheep
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Hatay Mustafa Kemal University
Hatay Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Metrikler
1
Atıf
7
Yazar
5
Anahtar Kelime