Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep
Polish Journal of Veterinary Sciences · Ocak 2023
YÖKSİS Kayıtları
The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
PROFESÖR MAHMUT OK →
The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep
Polish Journal of Veterinary Sciences · 2023 SCI-Expanded
DOÇENT MERVE İDER →
The effect of tilmicosin and diclofenac sodium combination on cardiac biomarkers in sheep
Polish journal of veterinary sciences · 2023 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa26 · 5-12
Scopus ID2-s2.0-85151044739
Erişim🔓 Açık Erişim
Özet
The aim of this study was to investigate the cardiotoxic effect of the combination of tilmicosin and diclofenac sodium in sheep. Thirty-two sheep were used and were randomly divided into four equal groups as tilmicosin (T), diclofenac sodium (D), tilmicosin+diclofenac sodium (TD) and control (C) group. Group T received a single dose of tilmicosin, Group D was administered diclofenac sodium once a day for 3 days, and group TD was administered diclofenac and tilmicosin at the same doses as group T and D. Group C received NaCl in a similar way. The blood samples were taken before dosing and at 4th, 8th, 24th and 72nd hour post-dosing for measurement of cardiac markers such as H-FABP, cTn-I, CK-MB. H-FABP level of group TD was found to be significantly (p<0.05) higher than of group C at the 8th, 24th and 72nd hour and group D and T at the 72nd hour. cTn-I and CK-MB levels of group TD were found significantly (p<0.05) higher compared with other groups. In conclusion, the combined use of tilmicosin and diclofenac in sheep causes an increase in cardiac biomarkers and it can be stated that this combination of drugs may cause cardiac damage.
Yazarlar (7)
1
Ramazan Yildiz
2
D. Durna Corum
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
Merve Ider
ORCID: 0000-0003-2928-5452
5
O. Atik
6
M. Ok
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
cardiotoxicity
diclofenac
H-FABP
sheep
tilmicosin
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Mehmet Akif University
Burdur Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Hatay Mustafa Kemal
Hatay Turkey