Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Triglycerides predict plasma fibronectin in children with type I diabetes mellitus rather than diabetes.
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové · Ocak 2002
YÖKSİS Kayıtları
Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes Mellitus Rather than Diabetes
Acta Medica (Hradec Kralove, Czech Republic) · 2002 SCOPUS
DOÇENT RAMAZAN KOCABAŞ →
Makale Bilgileri
DergiActa medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové
Yayın TarihiOcak 2002
Cilt / Sayfa45 · 33-37
Scopus ID2-s2.0-0036053690
Erişim🔓 Açık Erişim
Özet
Fibronectins are adhesive proteins considered as markers of endothelial activation. Plasma fibronectin levels in diabetes mellitus (DM) have been found to be associated with atherosclerotic risk factors. This study was carried out to investigate plasma fibronectin and its relation with serum lipids, apolipoproteins AI, B100 and lp(a) in diabetic children. 35 children (19F/16M) with type I DM and 30 non-diabetic age and gender-matched controls were enrolled. Apolipoprotein and fibronectin concentrations were determined with nephelometric methods. Plasma fibronectin levels of the children with type I DM and the control group are not statistically different. HbA1c and triglycerides concentration are found to be significant predictors of plasma fibronectin in diabetic children, while effect of plasma cholesterol, apolipoprotein AI, B100 and lp(a) are insignificant. Diabetic children with triglycerides 1.13 mmol/l have elevated plasma fibronectin (median, 25th-75th percentiles; 29.6, 8.3-40.8 mg/dL) compared to the diabetic > or = 19.9, 8.6-30.7 mg/dL, p < 0.05) and non-diabetic children (16.6, 12.7-32.4 mg/dL, p < 0.01) with triglycerides < 1.13 mmol/L. On the other hand plasma fibronectin concentrations of diabetic and non-diabetic children with high triglycerides are not significantly different. In conclusion our data does not support the concept that plasma fibronectin is elevated in type I diabetes mellitus at least in children, but high plasma triglycerides secondary to diabetes or not is associated with higher FNp concentrations which may have implications on atherogenesis. Plasma cholesterol, apolipoproteins AI, B100 and lp(a) are not significant determinants of FNp in type I diabetic children.
Yazarlar (7)
1
Ayse Binnur Erbagci
2
Mehmet Tarakçioglu
3
Ahmet Erbagci
4
Mehmet Gözübüyük
5
N. Yilmaz
6
Rukiye Deveci
7
Ramazan Kocabaş
Kurumlar
Gaziantep Üniversitesi
Gaziantep Turkey
Metrikler
1
Atıf
7
Yazar