Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Acute effect of hemodialysis on serum levels of the proinflammatory cytokines
Mediators of Inflammation · Şubat 2003
YÖKSİS Kayıtları
Acute effect of hemodialysis on serum levels of the proinflammatory cytokines
Mediators of Inflammation · 2003 SCI-Expanded 28 atıf
Doç. Dr. RAMAZAN KOCABAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia Reperfusion in the Rat
2015 ISSN: 0962-9351 SSCI
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor and Other Biochemical Markers in Lipopolysaccharide Induced Endotoxemia in Brown Trout
2014 ISSN: 0962-9351 SCI
Prof. Dr. BURAK DİK →
Acute effect of hemodialysis on serum levels of the proinflammatory cytokines
2003 ISSN: 0962-9351 SCI-Expanded 28 atıf Q2
Doç. Dr. RAMAZAN KOCABAŞ →
Leptin levels in obese women with and without type 2 diabetes mellitus
2004 ISSN: 0962-9351 SCI-Expanded 4 atıf Q2
Doç. Dr. RAMAZAN KOCABAŞ →
Makale Bilgileri
ISSN09629351
Yayın TarihiŞubat 2003
Cilt / Sayfa12 · 15-19
Scopus ID2-s2.0-0037657884
Erişim🔓 Açık Erişim
Özet
CHRONIC inflammation is a common feature of end-stage renal disease, which carries a heightened risk of atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional risk factors for inflammation, such as increased risk of local graft and fistula infections, impure dialysate or bio-incompatible membranes. Our study was designed to determine whether a hemodialysis session leads to an acute substantial alteration in the plasma levels of the proinflammatory cytokines interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α, the T-lymphocyte activation factor soluble IL-2 receptor (sIL-2R), and an inflammation mediator and chemotactic granulocyte factor, IL-8, in end-stage renal disease patients receiving chronic intermittent HD. In this study, 21 (12 male/nine female) patients undergoing chronic hemodialysis were enrolled. The acute effect of a hemodialysis session on serum cytokine concentrations was assessed by comparison of pre-hemodialysis and post-hemodialysis determinations. Serum IL-1β, sIL-2R, IL-6, IL-8 and TNF-α levels were determined with chemiluminescence enzyme immunometric assays. A significant difference was not observed for IL-1β, IL-6, TNF-α, and sIL-2R concentrations in pre-hemodialysis and post-hemodialysis specimens (p > 0.05). Serum median (25th-75th percentiles) IL-8 concentration was 69.4 (34.9-110.3) pg/ml before hemodialysis, and decreased to 31.5 (18.0-78.8) pg/ml following hemodialysis (p: 0.006). Clearance of IL-8 increased by 0.47 ± 0.08 pg/ml for each unit increase in pre-dialysis IL-8 (p < 0.001) and decreased by 5.63 ± 2.59 pg/ml for each unit increase in pre-dialysis urea mmol/l (p < 0.05). In conclusion, the results of our study demonstrate that a hemodialysis session markedly decreases IL-8 concentration, which is significantly affected by pre-dialysis concentrations, indicating that removal of IL-8 is a concentration gradient-dependent action, but does not change the serum levels of IL-1β, sIL-2R, IL-6, and TNF-α, underlining importance of the structural characteristics of the molecules.
Yazarlar (5)
1
Mehmet Tarakçioglu
2
Ayse Binnur Erbagci
3
Celalettin Usalan
4
Rukiye Deveci
5
Ramazan Kocabaş
Anahtar Kelimeler
Clearance
Hemodialysis
Interleukin-8
Proinflammatory cytokines
Soluble interleukin-2 receptor
Kurumlar
Gaziantep Üniversitesi
Gaziantep Turkey
Scimago Dergi (ISSN Eşleşmesi)
Mediators of Inflammation
Q2
OA
SJR Skoru1,225
H-Index145
YayıncıJohn Wiley and Sons Ltd
ÜlkeUnited States
Cell Biology (Q2)
Immunology (Q2)
Metrikler
73
Atıf
5
Yazar
5
Anahtar Kelime