Scopus
YÖKSİS Eşleşti
Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
Hypertension in Pregnancy · Kasım 2014
YÖKSİS Kayıtları
Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia
Hypertension in Pregnancy · 2014 SCI-Expanded
DOÇENT RAMAZAN KOCABAŞ →
Increased serum heme oxygenase 1 levels as a diagnostic marker of oxidative stress in preeclampsia
HYPERTENSION IN PREGNANCY · 2014 SCI
DOÇENT RAMAZAN KOCABAŞ →
Makale Bilgileri
DergiHypertension in Pregnancy
Yayın TarihiKasım 2014
Cilt / Sayfa33 · 488-497
Scopus ID2-s2.0-84911476787
Özet
Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.
Yazarlar (6)
1
Haci K. Erdemli
2
Pinar Yildirimlar
3
Tayfun Yaşar Alper
4
Ramazan Kocabaş
5
Osman Salis
6
Abdulkerim Bedir
Anahtar Kelimeler
Heme oxygenase 1
N-myc downstream-regulated gene 1
Oxidative stress
Preeclampsia
Kurumlar
Corum Training and Research Hospital
Corum Turkey
Hitit University
Corum Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Metrikler
13
Atıf
6
Yazar
4
Anahtar Kelime