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Scopus YÖKSİS DOI Eşleşti SJR Q2

Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors

Journal of Molecular Structure · Ocak 2024

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YÖKSİS Kayıtları
Design, Synthesis and Biological Evaluation of Novel Ketone Derivatives Containing Benzimidazole and 1, 3, 4-Triazole as CA Inhibitors
Journal of Molecular Structure · 2023 SCI-Expanded
Dr. Öğr. Üyesi AYŞEN IŞIK →
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
Journal of Molecular Structure · 2024 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Design, synthesis and biological evaluation of novel ketone derivatives containing benzimidazole and 1,3,4-triazole as CA inhibitors
Journal of Molecular Structure · 2024 SCI-Expanded
Dr. Öğr. Üyesi AYŞEN IŞIK →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis, structural characterization, DFT calculations, molecular docking, and antimicrobial activity studies of some new oxazolo[4,5-b]pyridine derivatives
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis and spectral properties of pyrene based calix 4 arene
2013 ISSN: 0022-2860 SCI-Expanded
Prof. Dr. ÖZLEM ŞAHİN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI
Prof. Dr. BİLGE TANER →
Amine derivatized calix 4 arenes for sensitive extraction of cupric ion and formation of amine radical cation
2014 ISSN: 00222860 SCI
Prof. Dr. BEGÜM TABAKCI →
Determination of free radical on polycrystal of 4 4 bis chloroacetyl diphenylether An ESR study
2013 ISSN: 00222860 SCI
Prof. Dr. YUSUF CEYLAN →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 0022-2860 SCI
Prof. Dr. HATİCE TÜRK DAĞI →
An EPR study on radiation induced 4 hydroxyphenyl acetic acid polycrystalline
2015 ISSN: 00222860 SSCI
Prof. Dr. YUSUF CEYLAN →
Synthesis of novel chiral Schiff base and amino alcohol derivatives of calix 4 arene and chiral recognition properties
2012 ISSN: 00222860 SCI-Expanded 4 atıf
Prof. Dr. SERKAN ERDEMİR →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. SERKAN ERDEMİR →
A novel Schiff base bearing dopamine groups with tripodal structure Synthesis and its salen salophen bridged Fe Cr III capped complexes
2013 ISSN: 00222860 SCI-Expanded 1 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 13 atıf
Prof. Dr. AHMET OKUDAN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI 5 atıf
Prof. Dr. PERVİN SOYLU →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 00222860 SCI
Prof. Dr. PERVİN SOYLU →
Novel dipodal Schiff base compounds Synthesis characterization and spectroscopic studies
2015 ISSN: 00222860 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Nonlinear optical properties spectroscopic studies and structure of 2 hydroxy 3 methoxy N 2 chloro benzyl benzaldehyde imine
2004 ISSN: 00222860 SCI-Expanded 60 atıf
Prof. Dr. ASLI KARAKAŞ →
Nonlinear optical properties of some derivatives of salicylaldimine based ligands
2004 ISSN: 00222860 SCI-Expanded 65 atıf
Prof. Dr. ASLI KARAKAŞ →
The investigation of nonlinear optical properties of N 3 fluorophenyl naphthaldimine
2005 ISSN: 00222860 SCI-Expanded 22 atıf
Prof. Dr. ASLI KARAKAŞ →
Synthesis spectroscopic studies and nonlinear optical behavior of N N bis 2 hydroxy 1 naphthylmethylidene 1 methyl 1 2 diaminoethane N N O O nickel II
2006 ISSN: 00222860 SCI-Expanded 14 atıf
Prof. Dr. ASLI KARAKAŞ →

Makale Bilgileri

Dergi Journal of Molecular Structure
ISSN00222860
Yayın TarihiOcak 2024
Cilt / Sayfa1295
DOI10.1016/j.molstruc.2023.136770
Scopus ID2-s2.0-85173844631
Özet In this study, we synthesized a series of new benzimidazole-triazole (6a-6k) derivatives and characterized them by 1H NMR, 13C NMR, and HRMS. These compounds were evaluated for their inhibitory activity against hCA-I and hCA-II. All the compounds exhibited good hCA-I and hCA-II inhibitory activities with IC50 values in the range of 1.158 µM to 3.48 µM. Among all these compounds, compound 6j, with an IC50 value of 1.288 µM and 1.6197 µM, is the most active against hCA-I and hCA-II, respectively. Compounds 6a-6k were also evaluated for their cytotoxic effects on the L929 mouse fibroblast (normal) cell line. Enzyme inhibition kinetics showed all compounds 6a-6k to inhibit the enzyme by non-competitive. The most active compound 6j was subjected to molecular docking, which revealed their binding interactions with the enzyme's active site, confirming the experimental findings.

Yazarlar (8)

1
Ulviye Acar Çevik
ORCID: 0000-0003-3537-2544
2
Ayşen Işık
3
Ravikumar Kapavarapu
4
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
5
Hayrunnisa Nadaroglu
6
Hayrani Eren Bostancı
7
Yusuf Özkay
8
Zafer Asım Kaplancıklı

Anahtar Kelimeler

1,3,4-Triazole Benzimidazole Carbonic anhydrase Cytotoxicity Molecular docking

Kurumlar

Anadolu Üniversitesi
Eskisehir Turkey
Atatürk Üniversitesi
Erzurum Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Nirmala College of Pharmacy, Mangalagiri
Mangalagiri India
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Dergi sayfasına git

Metrikler

7
Atıf
8
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

AI
AYŞEN IŞIK
Dr. Öğr. Üyesi

Hızlı Erişim

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