Scopus
YÖKSİS Eşleşti
Benzimidazole-Containing Compounds as Anticancer Agents
ChemistrySelect · Ağustos 2024
YÖKSİS Kayıtları
Benzimidazole‐Containing Compounds as Anticancer Agents
ChemistrySelect · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ AYŞEN IŞIK →
Makale Bilgileri
DergiChemistrySelect
Yayın TarihiAğustos 2024
Cilt / Sayfa9
Scopus ID2-s2.0-85201684321
Özet
Cancer is the second leading cause of death today and remains a threat to human health. The advent of multi-drug resistance and adverse effects make the current first-line anti-cancer medicines inadequate, despite the fact that numerous efforts have been made in the field of cancer therapy and significant progress has been made in the diagnosis and treatment of cancer. Consequently, the development of novel anticancer drugs with high activity and minimal toxicity is imperative. The benzimidazole ring has attracted the attention of medicinal chemists due to its medicinal and pharmacological properties. The heterocyclic pharmacophore of benzimidazole is a crucial scaffold for developing pharmaceuticals and drugs. In this review, we summarized the recent progress of benzimidazole as a privileged scaffold for the discovery of anti-cancer agents based on biological targets, such as VEGFR (Vascular Endothelial Growth Factor), PI3 K inhibitors (Phosphoinositide 3-kinase), EGFR kinase inhibitors (Epidermal Growth Factor Receptor), PARPs (Poly ADP-ribose polymerases), Tubulin Polymerization, HAT/HDAC (histone acetylase/histone deacetylase), SphK1 (Sphingosine kinase-1 inhibitors), aromatase, carbonic anhydrase, and topoisomerase inhibitors. The last 5 years of literature have been reviewed and relevant studies have been summarized in this review.
Yazarlar (15)
1
Ulviye Acar Çevik
ORCID: 0000-0003-3537-2544
2
Ayşen Işık
3
Betül Kaya
4
Ravikumar Kapavarapu
5
Mithun Rudrapal
6
Gresa Halimi
7
Abdüllatif Karakaya
8
Zahra Maryam
9
Ismail Celik
ORCID: 0000-0002-8146-1663
10
Asaf Evrim Evren
11
Hakan Ünver
12
Emine Rana Bagci
13
Merve Yildirim
14
Yusuf Özkay
15
Zafer Asım Kaplancıklı
Anahtar Kelimeler
Anti-cancer agents
Benzimidazole
Structure-activity relationships
Kurumlar
Afyonkarahisar Health Sciences University
Afyonkarahisar Turkey
Anadolu Üniversitesi
Eskisehir Turkey
Bilecik Şeyh Edebali Üniversitesi
Bilecik Turkey
Bülent Ecevit University
Zonguldak Turkey
Erciyes Üniversitesi
Kayseri Turkey
Eskisehir Technical University
Eskisehir Turkey
Nirmala College of Pharmacy, Mangalagiri
Mangalagiri India
Selçuk Üniversitesi
Selçuklu Turkey
Vignans Foundation for Science Technology and Research University
Guntur India