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Scopus YÖKSİS DOI Eşleşti SJR Q2

Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies

Journal of Molecular Structure · Aralık 2022

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YÖKSİS Kayıtları
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Journal of Molecular Structure · 2022 SCI-Expanded
Prof. Dr. AHMET KOÇAK →
Benzimidazole-hydrazone derivatives: Synthesis, in vitro anticancer, antimicrobial, antioxidant activities, in silico DFT and ADMET studies
Journal of Molecular Structure · 2022 SCI-Expanded
Dr. Öğr. Üyesi AYŞEN IŞIK →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis, structural characterization, DFT calculations, molecular docking, and antimicrobial activity studies of some new oxazolo[4,5-b]pyridine derivatives
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis and spectral properties of pyrene based calix 4 arene
2013 ISSN: 0022-2860 SCI-Expanded
Prof. Dr. ÖZLEM ŞAHİN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI
Prof. Dr. BİLGE TANER →
Amine derivatized calix 4 arenes for sensitive extraction of cupric ion and formation of amine radical cation
2014 ISSN: 00222860 SCI
Prof. Dr. BEGÜM TABAKCI →
Determination of free radical on polycrystal of 4 4 bis chloroacetyl diphenylether An ESR study
2013 ISSN: 00222860 SCI
Prof. Dr. YUSUF CEYLAN →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 0022-2860 SCI
Prof. Dr. HATİCE TÜRK DAĞI →
An EPR study on radiation induced 4 hydroxyphenyl acetic acid polycrystalline
2015 ISSN: 00222860 SSCI
Prof. Dr. YUSUF CEYLAN →
Synthesis of novel chiral Schiff base and amino alcohol derivatives of calix 4 arene and chiral recognition properties
2012 ISSN: 00222860 SCI-Expanded 4 atıf
Prof. Dr. SERKAN ERDEMİR →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. SERKAN ERDEMİR →
A novel Schiff base bearing dopamine groups with tripodal structure Synthesis and its salen salophen bridged Fe Cr III capped complexes
2013 ISSN: 00222860 SCI-Expanded 1 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 13 atıf
Prof. Dr. AHMET OKUDAN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI 5 atıf
Prof. Dr. PERVİN SOYLU →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 00222860 SCI
Prof. Dr. PERVİN SOYLU →
Novel dipodal Schiff base compounds Synthesis characterization and spectroscopic studies
2015 ISSN: 00222860 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Nonlinear optical properties spectroscopic studies and structure of 2 hydroxy 3 methoxy N 2 chloro benzyl benzaldehyde imine
2004 ISSN: 00222860 SCI-Expanded 60 atıf
Prof. Dr. ASLI KARAKAŞ →
Nonlinear optical properties of some derivatives of salicylaldimine based ligands
2004 ISSN: 00222860 SCI-Expanded 65 atıf
Prof. Dr. ASLI KARAKAŞ →
The investigation of nonlinear optical properties of N 3 fluorophenyl naphthaldimine
2005 ISSN: 00222860 SCI-Expanded 22 atıf
Prof. Dr. ASLI KARAKAŞ →
Synthesis spectroscopic studies and nonlinear optical behavior of N N bis 2 hydroxy 1 naphthylmethylidene 1 methyl 1 2 diaminoethane N N O O nickel II
2006 ISSN: 00222860 SCI-Expanded 14 atıf
Prof. Dr. ASLI KARAKAŞ →

Makale Bilgileri

Dergi Journal of Molecular Structure
ISSN00222860
Yayın TarihiAralık 2022
Cilt / Sayfa1270
DOI10.1016/j.molstruc.2022.133946
Scopus ID2-s2.0-85136625455
Özet Based on the biologically active heterocycle compounds, a series of new benzimidazole-hydrazone derivatives (3a-3j) were synthesized, starting from 4-(6-chloro-1H-benzimidazol-2-yl) benzohydrazide. The synthesized compounds were characterized by 1H NMR, 13C NMR, and HRMS spectroscopic methods. The synthesized compounds were preliminarily evaluated for their in vitro antimicrobial, anticancer and antioxidant activity. The antimicrobial activity was checked against S. aureus ATCC 29213, E. coli ATCC 25922, and C. albicans ATCC 10231 by micro-dilution method. The findings exhibited that the compounds possessed moderate antimicrobial potential. The compounds were also checked for their in vitro anticancer activities against HT-29 (colorectal cancer cell line) using the MTT assay. It was observed that all the compounds 3a-3j showed weak antiproliferative activity against HT-29 cells. The compounds were also analyzed for their antioxidant capacity by Tas & Tos activity. The compound 3d showed a high anti-oxidative effect with 30.81 µmol H2O2 Equiv./L value. The lowest energy state of compound 3d was realized in DMSO medium by using the B3LYP method at 6–311G (d,p) level, the optimized geometry of it is about 0.50 and 17 kcal/ mol more stable than in other solvents and the gas phase, respectively. The lower ΔE=3.563 eV indicates the higher reactivity of compound 3d, this is compatible with biological experimental data and shows high antioxidant property of the compound. In silico ADMET studies of compound 3d were performed. Indexing of the X-ray powder diffraction pattern was performed for compound 3a.

Yazarlar (10)

1
Ayşen Işık
2
Ulviye Acar Çevik
ORCID: 0000-0003-3537-2544
3
Ismail Celik
ORCID: 0000-0002-8146-1663
4
Hayrani Eren Bostancı
5
Arzu Karayel
6
Gülsüm Gündoğdu
7
Ufuk İnce
8
Ahmet Kocak
9
Yusuf Özkay
10
Zafer Asım Kaplancıklı

Anahtar Kelimeler

ADMET Anticancer Antimicrobial Antioxidant Benzimidazole DFT PXRD

Kurumlar

Anadolu Üniversitesi
Eskisehir Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Erciyes Üniversitesi
Kayseri Turkey
Hitit University
Corum Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Turkish-German University
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Dergi sayfasına git

Metrikler

36
Atıf
10
Yazar
7
Anahtar Kelime

Sistemimizdeki Yazarlar

AK
AHMET KOÇAK
Prof. Dr.

Hızlı Erişim

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