Scopus
YÖKSİS Eşleşti
Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease
Archives of Dermatological Research · Ocak 2006
YÖKSİS Kayıtları
Evaluation of the association between null genotypes ofglutathione S transferases and Behcet s disease
ARCHIVES OF DERMATOLOGICAL RESEARCH · 2006 SSCI 5 atıf
PROFESÖR NİLSEL OKUDAN →
Evaluation of the association between null genotypes of glutathione S transferases and Behcet s disease
Archives of Dermatological Research · 2006 SSCI
PROFESÖR HASAN ACAR →
Makale Bilgileri
DergiArchives of Dermatological Research
Yayın TarihiOcak 2006
Cilt / Sayfa297 · 289-293
Scopus ID2-s2.0-29044445931
Özet
Glutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 ± 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 ± 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and β-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1. © Springer-Verlag 2005.
Yazarlar (6)
1
S. Uzunoǧlu
2
Hasan Acar
3
Nilsel Okudan
4
Hakkl Gökbel
5
Inci Mevlitoglu
6
Fatih Sari
Anahtar Kelimeler
Behcet's disease
GST-M1
GST-T1
Null genotypes
Oxidative stress
Kurumlar
Manisa Celâl Bayar Üniversitesi
Manisa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
6
Yazar
5
Anahtar Kelime