Scopus
YÖKSİS Eşleşti
The association of nocturnal serum melatonin levels with major depression in patients with acute multiple sclerosis
Psychiatry Research · Kasım 2008
YÖKSİS Kayıtları
The association of nocturnal serum melatonin levels with majordepression in patients with acute multiple sclerosis
PSYCHIATRY RESEARCH · 2008 SSCI 3 atıf
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Makale Bilgileri
DergiPsychiatry Research
Yayın TarihiKasım 2008
Cilt / Sayfa161 · 253-257
Scopus ID2-s2.0-54049091063
Özet
The association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD). The sample comprised 13 patients with MD and 12 with no psychiatric disorders admitted to our clinic due to acute MS attacks. Psychiatric evaluation was performed with the Structured Clinical Interview for DSM-IV (SCD-I). The level of depressive symptoms was assessed with the Beck Depression Scale (BDS). Blood samples were taken from the patients to determine melatonin level at 03.30h and 10.00h before steroid treatment started. Melatonin levels were determined using the ELISA test. Nocturnal serum melatonin levels (21.2 ± 17.1 pg/ml) of the patients with MD were significantly lower than those (51.5 ± 18.3 pg/ml) of the patients without MD. A significant negative correlation was found between BDS scores and nocturnal serum melatonin levels. These findings suggest that a melatonin deficiency may be among the factors involved in the occurence of depression in MS patients. © 2007 Elsevier Ireland Ltd. All rights reserved.
Yazarlar (6)
1
Zehra Akpinar
2
Serhat Tokgöz
3
H. Gökbel
4
Nilsel Okudan
5
Faruk Uguz
6
Gülsüm Yilmaz
Anahtar Kelimeler
Circadian rhythms
Demyelinating diseases
Depression
Melatonin
Multiple sclerosis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
62
Atıf
6
Yazar
5
Anahtar Kelime