Scopus
YÖKSİS Eşleşti
Effects of grape seed polyphenols on oxidative damage in liver tissue of acutely and chronically exercised rats
Phytotherapy Research · Mayıs 2013
YÖKSİS Kayıtları
Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue ofAcutely and Chronically Exercised Rats
PHYTOTHERAPY RESEARCH · 2013 SSCI 5 atıf
PROFESÖR NİLSEL OKUDAN →
Effects of Grape Seed Polyphenols on Oxidative Damage in Liver Tissue of Acutely and Chronically Exercised Rats
Phytotherapy Research · 2013 SCI
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiPhytotherapy Research
Yayın TarihiMayıs 2013
Cilt / Sayfa27 · 672-677
Scopus ID2-s2.0-84876464382
Özet
The objective of the present study was to investigate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant defense markers in liver tissue of acutely and chronically exercised rats. Rats were randomly assigned to six groups: Control (C), Control Chronic Exercise (CE), Control Acute Exercise (AE), GSE-supplemented Control (GC), GSE-supplemented Chronic Exercise(GCE) and GSE-supplemented Acute Exercise (GAE). Rats in the chronic exercise groups were subjected to a six-week treadmill running and in the acute exercise groups performed an exhaustive running. Rats in the GSE supplemented groups received GSE (100 mg.kg-1.day-1) in drinking water for 6 weeks. Liver tissues of the rats were taken for the analysis of malondialdehyde (MDA), nitric oxide (NO) levels and total antioxidant activity (AOA) and xanthine oxidase (XO) activities. MDA levels decreased with GSE supplementation in control groups but increased in acute and chronic exercise groups compared to their non-supplemented control. NO levels increased with GSE supplementation. XO activities were higher in AE group compared to the CE group. AOA decreased with GSE supplementation. In conclusion, while acute exercise triggers oxidative stress, chronic exercise has protective role against oxidative stress. GSE has a limited antioxidant effect on exercise-induced oxidative stress in liver tissue. Copyright © 2012 John Wiley & Sons, Ltd.
Yazarlar (4)
1
Muaz Belviranli
2
H. Gökbel
3
Nilsel Okudan
4
Sadik Büyükbaş
Anahtar Kelimeler
exercise
grape seed extract
liver
oxidative stress
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
17
Atıf
4
Yazar
4
Anahtar Kelime