Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Donepezil-induced response of spirulina supplemented rat urinary bladder
Bratislava Medical Journal · Haziran 2013
YÖKSİS Kayıtları
Donepezil induced response of Spirulina supplemented rat urinary bladder
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY · 2013 SSCI
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiHaziran 2013
Cilt / Sayfa114 · 308-310
Scopus ID2-s2.0-84878940602
Erişim🔓 Açık Erişim
Özet
Objective: At present, very little is known about the effects of donepezil on vascular reactivity. The aim of the present study was to evaluate the responses of rat urinary bladder to donepezil (10-10-3x10-4 M) and the role of Spirulina supplementation in these effects. Material and methods: Animals were divided into the two groups of six animals in each group. The first group received only distilled water daily as vehicle for six weeks and served as the control. The second group received Spirulina 750 mg kg-1 orally, daily for six weeks and served as the spirulina group. Preparations of rat urinary bladder were used from both groups. Results: Donepezil produced concentration dependent relaxation of rat urinary bladder preparations pre-contracted with KCl. The pIC50 value, but not the maximal response of donepezil, was significantly lower (p<0.05) in the Spirulina supplemented group. Conclusions: These results demonstrated for the first time that spirulina treatment can affect urinary bladder activity.
Yazarlar (4)
1
Kismet Esra Nurullahoglu-Atalik
2
Nilsel Okudan
3
H. Gökbel
4
Z. U. Nurullahoglu
Anahtar Kelimeler
Donepezil
Rat
Spirulina
Urinary bladder
Kurumlar
Marmara Üniversitesi
Istanbul Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey