Scopus
YÖKSİS Eşleşti
Coenzyme Q10 supplementation and diastolic heart functions in hemodialysis patients: A randomized double-blind placebo-controlled trial
Hemodialysis International · Temmuz 2013
YÖKSİS Kayıtları
Coenzyme Q10 supplementation and diastolic heart functions inhemodialysis patients A randomized double blind placebo controlledtrial
HEMODIALYSIS INTERNATIONAL · 2013 SSCI
PROFESÖR NİLSEL OKUDAN →
Coenzyme Q10 Supplementation and Diastolic Heart Functions in Hemodialysis Patients: A Randomized Double-Blind Placebo-Controlled Trial
Hemodialysis International · 2013 SCI-Expanded
PROFESÖR ZEYNEP BIYIK →
Makale Bilgileri
DergiHemodialysis International
Yayın TarihiTemmuz 2013
Cilt / Sayfa17 · 374-381
Scopus ID2-s2.0-84879600702
Özet
Coenzyme Q10 (CoQ10) supplementation has been shown to improve diastolic heart function in various patient cohorts. Systolic and diastolic dysfunctions are common in patients with end-stage renal disease. Favorable effects of CoQ10 on cardiac functions are yet to be seen in hemodialysis patients. We aimed to evaluate effect of CoQ10 supplementation on diastolic function in a cohort of maintenance hemodialysis patients. This was a prospective, double-blind, placebo-controlled, crossover study in which all patients received placebo and oral CoQ10 200mg/d during the 8 weeks in each phase, with a 4-week washout period. Participants underwent conventional and tissue Doppler echocardiography before and after each study phase. Parameters characterizing left ventricle diastolic function and other standard echocardiographic measurements were recorded. Twenty-eight patients were randomized, but 22 patients completed study protocol. Intraventricular septum (IVS) thickness and left ventricle mass were significantly decreased in CoQ10 group (P = 0.03 and P = 0.01, respectively). Myocardial peak systolic and early diastolic velocities derived from IVS were significantly increased (P = 0.048 and P = 0.04, respectively). Isovolumetric relaxation time and E/Em ratio calculated for IVS also significantly reduced in CoQ10 group (p = 0.02 and p = 0.04, respectively). There was no significant difference in any of the studied echocardiographic parameters in placebo group. The results of this study showed that CoQ10 supplementation did not significantly improved diastolic heart functions compared with placebo in maintenance hemodialysis patients. © 2013 The Authors. Hemodialysis International © 2013 International Society for Hemodialysis.
Yazarlar (11)
1
Suleyman Turk
2
Aysegul Baki
3
Yalcin Solak
4
Mehmet Kayrak
5
Huseyin Atalay
6
Abduzhappar Gaipov
7
Alpay Aribas
8
Hakan Akilli
9
Zeynep Bıyık
10
Nilsel Okudan
11
H. Gökbel
Anahtar Kelimeler
Coenzyme Q10
Diastolic heart function
Echocardiography
Hemodialysis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
11
Yazar
4
Anahtar Kelime