Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The comparison of preemptive analgesic effects of curcumin and diclofenac
Bratislava Medical Journal · Ocak 2014
YÖKSİS Kayıtları
The comparison of preemptive analgesic effects of curcumin and diclofenac
Bratislava Medical Journal · 2014 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
The comparison of preemptive analgesic effects of curcumin and diclofenac
Bratislava Medical Journal · 2014 SCI-Expanded
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2014
Cilt / Sayfa115 · 757-760
Scopus ID2-s2.0-84921371086
Erişim🔓 Açık Erişim
Özet
Objective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg-1, p.o.) and diclofenac (10 mg kg-1, i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcumin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac.
Yazarlar (4)
1
Kismet Esra Nurullahoglu-Atalik
2
Nilsel Okudan
3
Muaz Belviranli
4
Mehmet Öz
Anahtar Kelimeler
Curcumin
Diclofenac
Preemptive analgesic effect
Rat
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
4
Yazar
4
Anahtar Kelime