Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of grape seed extract on oxidative stress and antioxidant defense markers in streptozotocin-induced diabetic rats
Turkish Journal of Medical Sciences · Ocak 2015
YÖKSİS Kayıtları
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
TURKISH JOURNAL OF MEDICAL SCIENCES · 2015 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
TURKISH JOURNAL OF MEDICAL SCIENCES · 2015 SCI-Expanded
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2015
Cilt / Sayfa45 · 489-495
Scopus ID2-s2.0-84929725029
Erişim🔓 Açık Erişim
Özet
Background/aim: To evaluate the effects of grape seed extract (GSE) supplementation on oxidative stress and antioxidant markers in streptozotocin (STZ)-induced diabetic rats. Materials and methods: Tirty-six male rats were divided into the following four groups: control, GSE-supplemented control, diabetic, and GSE-supplemented diabetic. Beginning on day 7 afer STZ injection, the rats were administered GSE (100 mg kg<sup>–1</sup> day<sup>–1</sup>) in drinking water for 6 weeks. At the end of week 6, rats were sacrifced by cardiac puncture. Plasma nitric oxide (NO) levels and xanthine oxidase (XO), adenosine deaminase (ADA), and glutathione peroxidase (GPx) activities were analyzed. Results: Both XO and ADA activities increased and NO levels decreased in diabetic rats (P < 0.05). GSE supplementation normalized all of these changes. Antioxidant enzyme activities decreased in diabetic rats compared to the controls (P < 0.05). GSE supplementation increased antioxidant enzyme activities in both diabetic and healthy rats (P < 0.05). Conclusion: Tese fndings suggest that 6 weeks of oral GSE supplementation may prevent oxidative stress and improve antioxidant status in diabetic rats.
Yazarlar (4)
1
Muaz Belviranli
2
H. Gökbel
3
Nilsel Okudan
4
Sadik Büyükbaş
Anahtar Kelimeler
Adenosine deaminase
Antioxidant enzyme activity
Experimental diabetes
Grape seed extract
Nitric oxide
Oxidative stress
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
4
Yazar
6
Anahtar Kelime