Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
Journal of Basic and Clinical Physiology and Pharmacology · Ocak 2019
YÖKSİS Kayıtları
The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
Journal of Basic and Clinical Physiology and Pharmacology · 2019 Biological Abstracts | BIOSIS Previews
PROFESÖR MUAZ BELVİRANLI →
The effect of silymarin supplementation on cognitive impairment induced by diabetes in rats
Journal of Basic and Clinical Physiology and Pharmacology · 2019 Biological Abstracts | BIOSIS Previews
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiJournal of Basic and Clinical Physiology and Pharmacology
Yayın TarihiOcak 2019
Cilt / Sayfa30
Scopus ID2-s2.0-85064947112
Erişim🔓 Açık Erişim
Özet
The objective of this investigation was to examine the impact of silymarin supplementation on locomotion, anxiety-related behavior, learning, and memory via several behavioral tests, such as open field, elevated plus maze, and Morris water maze tests in streptozotocin-induced diabetic rats. The rats were divided into the control, diabetes, silymarin, and diabetes plus silymarin groups. On the 30th-35th days of the study, several behavioral tests were performed and blood and brain tissue samples were taken and brain-derived neurotrophic factor (BDNF) and histone deacetylase 3 (HDAC3) levels were analyzed. There was no significant difference in locomotor activity between the groups (p = 0.534). Spatial memory was lower (p = 0.000) but anxiety scores were higher (p = 0.005) in the diabetes group than in the control, silymarin, and diabetes plus silymarin groups. Plasma (p = 0.000) and brain tissue (p = 0.007) BDNF levels were lower in the diabetes group than in the control, silymarin, and diabetes plus silymarin groups; however, plasma (p = 0.432) and brain tissue (p = 0.321) HDAC3 levels did not significantly differ between the groups. The findings obtained from this study suggest that silymarin supplementation could improve anxiety-related behavior, and learning and memory in diabetic rats by increasing the BDNF levels.
Yazarlar (3)
1
Burcu Yön
2
Muaz Belviranll
3
Nilsel Okudan
Anahtar Kelimeler
BDNF
cognitive function
diabetes
HDAC3
learning
silymarin
Kurumlar
Düzce Üniversitesi
Duzce Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
14
Atıf
3
Yazar
6
Anahtar Kelime