Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Comparison of the effect of postweaning social isolation, enriched environment, and exercise training on learning and memory functions in rats
Turkish Journal of Medical Sciences · Ocak 2023
YÖKSİS Kayıtları
Comparison of the effect of postweaning social isolation, enriched environment, and exercise training on learning and memory functions in rats
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2023 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
Comparison of the effect of postweaning social isolation, enriched environment, and exercise training on learning and memory functions in rats
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2023 SCI-Expanded
Prof. Dr. NİLSEL OKUDAN →
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Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2023
Cilt / Sayfa53 · 1412-1420
Scopus ID2-s2.0-85175612983
Erişim🔓 Açık Erişim
Özet
Background/aim: To assess the effects of postweaning social isolation, an enriched environment, and exercise training on learning and memory functions in rats, as well as their relation with the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) concentrations in the hippocampus. Materials and methods: Randomly assigned into 4 groups were 35 female postweaning rats (25 day old), as the control (C), social isolation (SI), enriched environment (EE), and exercise training (E) groups. The SI and the EE groups were housed under their specific conditions and the E and the C groups were housed under standard conditions for 6 weeks. The rats in the E group swam for 60 min/ day, 5 days a week, for 6 weeks. After 6 weeks, the rats were evaluated in the Morris water maze (MWM). Following MWM assessment, hippocampal tissue and blood samples were taken to measure the BDNF and NGF. Results: According to the results of the MWM probe trial session, the thigmotaxis behavior was higher in the SI group compared to the C group (p < 0,05). Furthermore, the time spent in the target quadrant (quadrant with an escape platform) was lower in the SI group compared to the EE group (p < 0.05). The BDNF and NGF levels in the hippocampus and plasma were not different between the groups (p ˃ 0.05). Conclusion: Postweaning social isolation may increase thigmotaxis behaviors. Postweaning social isolation, enriched environment, and exercise training did not affect the spatial learning, memory function, hippocampal BDNF or NGF levels in female rats.
Yazarlar (3)
1
Hatice Ekinalan Kayhan
2
Nilsel Okudan
3
Muaz Belviranli
Anahtar Kelimeler
brain-derived neurotrophic factor
environment
exercise training
Morris water maze test
nerve growth factor
Social isolation
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
1
Atıf
3
Yazar
6
Anahtar Kelime