Scopus
🔓 Açık Erişim
Determination of the cytotoxic effect on human colon cancer and phenolic substance content of the endemic species sideritis Ozturkii Aytaç & Aksoy
Applied Ecology and Environmental Research · Ocak 2019
Makale Bilgileri
DergiApplied Ecology and Environmental Research
Yayın TarihiOcak 2019
Cilt / Sayfa17 · 7407-7419
Scopus ID2-s2.0-85070482570
Erişim🔓 Açık Erişim
Özet
Sideritis L. species that we based on in this study are annual or perennial flowering plants which are widely used as herbal medicine, and also called mountain tea or shepherd’s tea. They are common in the Mediterranean Region, the Balkans, Iberian Peninsula, Greece, Central Asia and Anatolia. They are xerophytic shrub or herbs between 8 and 90 cm. They usually grow on arid cliffs, calcareous slopes, high-altitude mountainous regions (650-1400 m). Full bloom usually occurs in July. It is commonly used in Albania, Greece, Kosova, Bulgaria, Macedonia, Asia, Central Europe and Anatolia as herbal tea and for therapeutic purposes. It is usually used to aid digestion, strengthen the immune system, suppress common cold, allergy, sinusitis and influenza and as therapeutic for pain and mild anxiety. The methanol extracts obtained from the flower and leaf parts of the species Sideritis ozturkii Aytaç & Aksoy, which is endemic in Turkey, were applied at different concentrations and for different times on DLD-1 human colorectal cancer cells cultured in RPMI-1640 medium. The cytotoxicity measurements were made through the use of MTT and the cytotoxicity indices were calculated using an Elisa Reader. As a result of the study, it was determined that the flower and leaf extracts obtained from the species Sideritis ozturkii exhibit cytotoxic activity on DLD-1 cells in a dose-and time-dependent manner. It is believed that the extracts obtained from the species Sideritis ozturkii could be beneficial as a natural anti-proliferative agent.
Yazarlar (2)
1
Hakkı Demirelma
2
E. Gelinci
Anahtar Kelimeler
Cancer
Cytotoxicity
DLD-1
MTT
Phenolic
Sideritis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
2
Yazar
6
Anahtar Kelime