Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method
Journal of Research in Pharmacy · Ocak 2022
YÖKSİS Kayıtları
Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method
Journal of Research in Pharmacy · 2022 Emerging Sources Citation Index
DOKTOR ÖĞRETİM ÜYESİ YAKUP GÜLTEKİN →
Makale Bilgileri
DergiJournal of Research in Pharmacy
Yayın TarihiOcak 2022
Cilt / Sayfa26 · 1608-1618
Scopus ID2-s2.0-85142139035
Erişim🔓 Açık Erişim
Özet
A simple, rapid and reproducible HPLC method has been developed and validated for the quantification of albendazole sulfoxide (ALBSOX) and praziquantel (PRZ), which can coexist in various dosage forms. Chromatographic separation was performed in gradient mode using a mobile phase consisting of an InertSustain® C18 column (150 × 4.6 mm, 5 µm) and acetonitrile: water (v/v) at a flow rate of 1.0 mL/min. The active substance peaks were well separated and detected by a DAD detector at 217 nm. The HPLC method was linear for ALBSOX and PRZ in the concentration range of 0.1-50 µg/mL. Limit of detection (LOD) was found to be 0.01 µg/mL for ALBSOX and 0.009 µg/mL for PRZ. The limit of quantification (LOQ) was found to be 0.03 µg/mL for ALBSOX and 0.027 µg/mL for PRZ. The developed HPLC method was validated based on ICH guidelines for specificity, linearity, system suitability, precision and accuracy. The method was applied for simultaneous quantification and characterization studies of ALBSOX and PRA in PLGA nanoparticles.
Yazarlar (8)
1
Yakup Gultekin
2
Naile Öztürk
3
Ayhan Filazi
ORCID: 0000-0002-2800-6215
4
Ahmet Deniz
5
Çağla Korkmaz
6
Esra Pezik
7
Gözde Barin
8
İmran Vural
Anahtar Kelimeler
Albendazole sulfoxide
HPLC method
nanoparticle
praziquantel
validation
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Inönü Üniversitesi
Malatya Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Veterinary Control Central Research Institute
Ankara Turkey
Metrikler
4
Atıf
8
Yazar
5
Anahtar Kelime