Scopus
YÖKSİS Eşleşti
Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery
Drug Development and Industrial Pharmacy · Ocak 2024
YÖKSİS Kayıtları
Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY · 2024 SCI
DOKTOR ÖĞRETİM ÜYESİ YAKUP GÜLTEKİN →
Makale Bilgileri
DergiDrug Development and Industrial Pharmacy
Yayın TarihiOcak 2024
Cilt / Sayfa50 · 706-719
Scopus ID2-s2.0-85201239271
Özet
Objective: In the current research, 6-gingerol (GA)-loaded nanofiber drug delivery system were developed, and their potential usage in wound healing was evaluated. Significance: This study investigates the effectiveness of nanofibrous membranes composed of sodium alginate (SA), poly(vinyl alcohol) (PVA), and 6-gingerol (GA) as delivery systems for anti-inflammatory agents in the context of wound dressings. Methods: GA-loaded SA/PVA nanofiber was prepared using electrospinning. In vitro characterization of this nanofiber included the examination of comprehensive in vitro characterization, anti-inflammatory and antioxidant activities, cytotoxicity, a scratch tes and in vivo skin test. Results: GA was extracted from Zingiber officinale, and its successful isolation was confirmed through analyses such as H-NMR, C-NMR. Then GA was electrospuned into the SA/PVA nanofibers, and scanning electron microscopy (SEM) imaging revealed that the fiber diameters of the formulations ranged between 148 nm and 176 nm. Anti-inflammatory and antioxidant studies demonstrated that the effectiveness of GA increased with higher doses; however, this increase was accompanied by decreased cell viability. In vitro release studies revealed that GA exhibited a burst release within the first 8 h, followed by a controlled release, reaching completion within 24 h. Within the scope of in vitro release kinetics, release data are mathematically compatible with the Weibull model with high correlation. The scratch test results indicated that TB2 (%1 GA) promoted epithelialization. Furthermore, it was determined that TB2 (%1 GA) did not cause any irritation. Conclusions: As a result, TB2 shows promise as a formulation for wound dressings, offering potential benefits in the field of wound care.
Yazarlar (10)
1
Heybet Kerem Polat
2
Sefa Gözcü
ORCID: 0000-0002-0735-4229
3
Sedat Ünal
4
Timur Paçacı
5
Eren Aytekin
6
Nasıf Fatih Karakuyu
7
Esra Köngül Şafak
8
Yakup Gultekin
9
Yonca Yazıksız
10
Nihat Kurt
Anahtar Kelimeler
6-gingerol
nanofiber
poly(vinyl alcohol)
release kinetic
scratch test
sodium alginate
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey