Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Formulation of hesperidin-loaded in situ gel for ocular drug delivery: a comprehensive study
Journal of the Science of Food and Agriculture · Ağustos 2024
YÖKSİS Kayıtları
Formulation of hesperidin-loaded in situ gel for ocular drug delivery: a comprehensive study
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE · 2024 SCI
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Molecular characterization of mulberry Morus spp genotypes via RAPD and ISSR
2012 ISSN: 00225142 SCI-Expanded
Prof. Dr. LÜTFİ PIRLAK →
Effects of vacuum packing on eggshellmicrobial activity and egg quality in table eggsunder different storage temperatures
2013 ISSN: 0022-5142 SCI
Prof. Dr. ALİ AYGÜN →
Effect of ultrasonic treatment on reduction of Esherichia coli ATCC 25922 and egg quality parameters in experimentally contaminated hens shell eggs
2013 ISSN: 0022-5142 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
MOLECULAR CHARACTERIZATION OF MULBERRY (Morus Spp) GENOTYPES VIA RAPD AND ISSR
2012 ISSN: 00225142 SCI-Expanded
Prof. Dr. MUZAFFER İPEK →
Effects of sowing and harvesting dates on yield and some quality characteristic of crops in sugar beet cereal rotation system
2008 ISSN: 0022-5142 SCI-Expanded 3 atıf
Prof. Dr. ÖZDEN ÖZTÜRK →
Growth and mineral acquisition response of grapevine rootstocks Vitis spp to inoculation with different strains of plant growth promoting rhizobacteria PGPR
2012 ISSN: 00225142 SCI-Expanded 7 atıf
Prof. Dr. ALİ SABIR →
The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties Vitis spp
2012 ISSN: 00225142 SCI-Expanded 7 atıf
Prof. Dr. ALİ SABIR →
Mineral contents of some aromatic plants their growth soils ana infusions
2008 ISSN: 0022-5142 SCI-Expanded 6 atıf
Prof. Dr. SAİT GEZGİN →
The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties Vitis spp
2012 ISSN: 00225142 SSCI 8 atıf
Prof. Dr. ZEKİ KARA →
Evaluation of ISSR markers for genetic diversity analysis in Anatolian Water Buffaloes
2011 ISSN: 00225142 SSCI 1 atıf
Prof. Dr. SAİM BOZTEPE →
Forage yields and feeding value of small grain winter cereals for lambs
2016 ISSN: 00225142 SCI
Prof. Dr. MUSTAFA SELÇUK ALATAŞ →
Mineral contents of some aromatic plants their growth soils and infusions
2008 ISSN: 0022-5142 SCI-Expanded
Prof. Dr. UMMAHAN ÇETİN KARACA →
Mineral contents of 34 species of edible mushrooms growing wild in
Turkey
2006 ISSN: 0022-5142 SCI
Öğr. Gör. NESİM DURSUN →
Influence of Eriophyid mites (Aculus olearius Castagnoli and Aceria oleae (Nalepa) (Acarina: Eriophyidae)) on some physical and chemical characteristics of Ayvalık variety olive fruit
2011 ISSN: 00225142 SCI
Doç. Dr. HÜSEYİN ÇETİN →
Effects of sowing and harvesting dates on yield and some quality characteristics of crops in sugar beet cereal rotation system
2008 ISSN: 0022-5142 SCI-Expanded 3 atıf
Prof. Dr. ALİ TOPAL →
The effects of different spices and fat types on the formation of heterocyclic aromatic amines in barbecued sucuk
2018 ISSN: 0022-5142 SCI-Expanded Q1
Doç. Dr. KÜBRA ÜNAL →
Detection of central nervous system tissue as bovine spongiform encephalopathy specified risk material in traditional Turkish meat
2012 ISSN: 0022-5142 SCI-Expanded
Prof. Dr. YUSUF DOĞRUER →
Evaluation of ISSR markers for genetic diversity analysis in Anatolian Water Buffaloes
2011 ISSN: 00225142 SCI
Prof. Dr. İBRAHİM AYTEKİN →
Untargeted metabolomic profiling of three Crataegus species (Hawthorn) and their in vitro biological activities
2019 ISSN: 0022-5142 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Screening Lactobacillus strains from artisanal Turkish goatskin casing Tulum cheeses produced by nomads via molecular and in vitro probiotic characteristics
2021 ISSN: 0022-5142 SCI-Expanded Q1
Doç. Dr. TALHA DEMİRCİ →
Makale Bilgileri
ISSN00225142
Yayın TarihiAğustos 2024
Cilt / Sayfa104 · 5846-5859
Scopus ID2-s2.0-85188449159
Erişim🔓 Açık Erişim
Özet
BACKGROUND: Allergic conjunctivitis is one of the most common eye disorders. Different drugs are used for its treatment. Hesperidin is an active substance isolated from Citrus sinensis L. (Rutaceae) fruit peels, with known anti-inflammatory activity but low solubility. It was complexed with cyclodextrin and encapsulated in situ gel to extend its duration in the eye. RESULTS: The optimized formulation comprised 1% hesperidin, 1.5% hydroxyethyl cellulose, and 16% poloxamer 407. The viscosity at 25 °C was 492 ± 82 cP, and at 35 °C it was 8875 ± 248 cP, the pH was 7.01 ± 0.03, gelation temperature was 34 ± 1.3 °C, and gelation time was 33 ± 1.2 s. There was a 66% in vitro release in the initial 2 h, with a burst effect. A lipoxygenase (LOX) inhibition test determined that hesperidin was active at high doses on leukotyrens seen in the body in allergic diseases. In cell-culture studies, the hesperidin cyclodextrin complex loaded in situ gel, BRN9-CD (poloxamer 16%, hydroxy ethyl cellulose (HEC) 1.5%), enhanced cell viability in comparison with the hesperidin solution. It was determined that BRN9-CD did not cause any irritation in the ocular tissues in the Draize test. CONCLUSION: The findings of this study demonstrate the potential of the in situ gel formulation of hesperidin in terms of ease of application and residence time on the ocular surface. Due to its notable LOX inhibition activity and positive outcomes in the in vivo Draize test, it appears promising for incorporation into pharmaceutical formulations. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Yazarlar (12)
1
Sefa Gözcü
ORCID: 0000-0002-0735-4229
2
Heybet Kerem Polat
3
Yakup Gultekin
4
Sedat Ünal
5
Nasıf Fatih Karakuyu
6
Esra Köngül Şafak
7
Osman Doğan
8
Esra Pezik
9
Muhammet Kerim Haydar
10
Eren Aytekin
11
Nihat Kurt
12
Burak Batuhan Laçin
Anahtar Kelimeler
cell viability
cyclodextrin
Draize test
hesperidin
lox inhibition
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Erciyes Üniversitesi
Kayseri Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Hacettepe Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
T.C. Sağlık Bakanlığı,
Ankara Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of the Science of Food and Agriculture
Q1
SJR Skoru0,760
H-Index199
YayıncıJohn Wiley and Sons Ltd
ÜlkeUnited Kingdom
Agronomy and Crop Science (Q1)
Food Science (Q1)
Biotechnology (Q2)
Nutrition and Dietetics (Q2)
Metrikler
20
Atıf
12
Yazar
5
Anahtar Kelime