Scopus
Causative pathogens and antibiotic resistance in diabetic foot infections: A prospective multi-center study
Journal of Diabetes and its Complications · Temmuz 2016
Makale Bilgileri
DergiJournal of Diabetes and its Complications
Yayın TarihiTemmuz 2016
Cilt / Sayfa30 · 910-916
Scopus ID2-s2.0-84959521823
Özet
Aim Clinical practice guidelines for the management of diabetic foot infections developed by the Infectious Diseases Society of America (IDSA) are commonly used worldwide. The issue of whether or not these guidelines need to be adjusted for local circumstances, however, has seldom been assessed in large prospective trials. Methods The Turk-DAY trial was a prospective, multi-center study in which infectious disease specialists from centers across Turkey were invited to participate (NCT02026830). Results A total of 35 centers throughout Turkey enrolled patients in the trial. Overall, investigators collected a total of 522 specimens from infected diabetic foot wounds for culture from 447 individual patients. Among all isolates, 36.4% were gram-positive organisms, with Staphylococcus aureus the most common among these (11.4%). Gram-negative organisms constituted 60.2% of all the isolates, and the most commonly isolated gram-negative was Escherichia coli (15%). The sensitivity rates of the isolated species were remarkably low for several antimicrobials used in the mild infection group. Conclusions Based on our findings, several of the antimicrobials frequently used for empirical treatment, including some also recommended in the IDSA guidelines, would not be optimal for treating diabetic foot infections in Turkey. Although the IDSA guideline recommendations may be helpful to guide empiric antimicrobial therapy of DFIs, they should be adjusted to local conditions.
Yazarlar (54)
1
Mustafa Hatipoglu
2
Mesut Mutluoglu
3
Vedat Turhan
4
Gunalp Uzun
5
Benjamin A. Lipsky
6
Erol Sevim
7
Hayati Demiraslan
8
Esma Eryilmaz Dogan
9
Cem Ozuguz
10
Ali Memis
11
Hakan Ay
12
Bilgin Arda
13
Serhat Uysal
14
Vicdan Koksaldi Motor
15
Cigdem Kader
16
Ayse Erturk
17
Omer Coskun
18
Fazilet Duygu
19
Selma Guler
20
Fatma Aybala Altay
21
Aziz Ogutlu
22
Sibel Bolukcu
23
Senol Yildiz
24
Ozlem Kandemir
25
Halide Aslaner
26
Arife Polat
27
Mustafa K. Karahocagil
28
Kadriye Kart Yasar
29
Emine Sehmen
30
Sirri Kilic
31
Mustafa Sunbul
32
Serap Gencer
33
Fatma Bozkurt
34
Tugba Yanik
35
Nefise Oztoprak
36
Ayse Batirel
37
Hamdi Sozen
38
Inci Kilic
39
Ilhami Celik
40
Bengisu Ay
41
Selma Tosun
42
Ayten Kadanali
43
Senol Çomoglu
44
Affan Denk
45
Salih Hosoglu
46
Ozlem Aydin
47
Nazif Elaldi
48
Serife Akalin
49
Bahar Kandemir
ORCID: 0000-0002-9815-8767
50
Ayhan Akbulut
51
Tuna Demirdal
52
Recep Balik
53
Emel Azak
54
Gonul Sengoz
Anahtar Kelimeler
Antibiotic therapy
Diabetic foot
Guideline
Infection
Turkey
Kurumlar
Ankara Numune Education and Research Hospital
Ankara Turkey
Antalya Education and Research Hospital
Antalya Turkey
Bak?rkoy Dr. Sadi Konuk Egitim ve Arast?rma Hastanesi
Istanbul Turkey
Bozok Üniversitesi
Yozgat Turkey
Canakkale Military Hospital
Canakkale Turkey
Cumhuriyet Üniversitesi Tip Fakültesi
Sivas Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Dr. Lutfi Kirdar Training and Research Hospital
Istanbul Turkey
Ege University Medical School
Izmir Turkey
Erciyes Üniversitesi
Kayseri Turkey
Eskisehir Military Hospital
Eskisehir Turkey
Firat Üniversitesi Tip Fakültesi
Elazig Turkey
Gülhane Eğitim ve Araştırma Hastanesi
Ankara Turkey
Haseki Education and Research Hospital
Istanbul Turkey
Hôpitaux Universitaires de Genève
Geneva Switzerland
İzmir Kâtip Çelebi Üniversitesi
Izmir Turkey
Kahramanmaras Sütçü Imam Üniversitesi
Kahramanmaras Turkey
Kocaeli Üniversitesi
İzmit Turkey
Mersin Üniversitesi Tip Fakültesi
Mersin Turkey
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Pamukkale Üniversitesi Tip Fakültesi
Denizli Turkey
Recep Tayyip Erdogan University
Rize Turkey
Sakarya Üniversitesi
Serdivan Turkey
Samsun Training and Research Hospital Samsun
Turkey
Şifa Üniversitesi
Izmir Turkey
Sultan 2.Abdülhamid Han Eğitim ve Araştirma Hastanesi
Uskudar Turkey
T.C. Saglik Bakanligi Istanbul Goztepe Egitim ve Arastirma Hastanesi
Goztepe Turkey
T. C. Sağlık Bakanlığı Ankara Diskapi Yildirim Beyazit Eğitim ve Araştirma Hastanesi
Ankara Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Umraniye Training and Research Hospital
Istanbul Turkey
University of Health Sciences
Istanbul Turkey
University of Oxford Medical Sciences Division
Oxford United Kingdom
Van Yüzüncü Yıl Üniversitesi
Van Turkey
Metrikler
42
Atıf
54
Yazar
5
Anahtar Kelime