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DNA damaging effect of paclitaxel in the epididymal sperms as a chemotherapeutic agent and possible remedies to prevent this effect: A study on reproductive potential of male cancer patients of reproductive age

Theriogenology · Temmuz 2019

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YÖKSİS Kayıtları
DNA Damaging Effect of Paclitaxel in the Epididymal Sperms as a Chemotherapeutic Agent and Possible Remedies to Prevent this Effect: A Study on Reproductive Potential of Male Cancer Patients of Reproductive Age
Theriogenology · 2019 SCI
Prof. Dr. MUSTAFA NUMAN BUCAK →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Protective effect of esterified glucomannan on aflatoxin inducedchanges in testicular function sperm quality and seminal plasmabiochemistry in rams
2014 ISSN: 0093-691X SSCI
Prof. Dr. EMRAH SUR →
Protective effect of esterified glucomannan on aflatoxin induced changes in testicular function sperm quality and seminal plasma biochemistry in rams
2014 ISSN: 0093691X SCI-Expanded
Prof. Dr. NURCAN DÖNMEZ →
The influence of trehalose taurine cysteamine and hyaluronan on ram semen
2007 ISSN: 0093691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of glutamine and sugars after bull spermatozoa cryopreservation
2011 ISSN: 0093691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Detection of Brucella canis from inguinal lymph nodes of naturally infected dogs by PCR
2010 ISSN: 0093691X SSCI
Prof. Dr. UÇKUN SAİT UÇAN →
Protective effect of esterified glucomannan on aflatoxin induced changes in testicular function sperm quality and seminal plasma biochemistry in rams
2014 ISSN: 0093691X SSCI
Prof. Dr. HASAN HÜSEYİN DÖNMEZ →
DNA Damaging Effect of Paclitaxel in the Epididymal Sperms as a Chemotherapeutic Agent and Possible Remedies to Prevent this Effect: A Study on Reproductive Potential of Male Cancer Patients of Reproductive Age
2019 ISSN: 0093-691X SCI Q1
Prof. Dr. MUSTAFA NUMAN BUCAK →
Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams
2014 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
The effect of anti-müllerian hormone and progesterone concentrations on superovulation response and embryo yield in goats
2020 ISSN: 0093-691X SCI
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
Chronological echocardiographic evaluation of left ventricular systolic and diastolic function in term and premature neonatal calves
2020 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. MERVE İDER →
Chronological echocardiographic evaluation of left ventricular systolic and diastolic function in term and premature neonatal calves
2020 ISSN: 0093-691X SCI-Expanded
Doç. Dr. AMİR NASERİ →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. HASAN ALKAN →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded Q1
Prof. Dr. KAMİL ÜNEY →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. MERVE İDER →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded
Prof. Dr. İBRAHİM AYDIN →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI Q1
Prof. Dr. KAMİL ÜNEY →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MAHMUT OK →
The effects of glutathione supplementation on post-thawed Turkey semen quality and oxidative stress parameters and fertilization, and hatching potential
2022 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of strategies to increase progesterone levels on fertility of bovine embryo transfer recipients - A meta-analysis
2024 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. HASAN ALKAN →
Effect of strategies to increase progesterone levels on fertility of bovine embryo transfer recipients - A meta-analysis
2024 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. FATMA SATILMIŞ →

Makale Bilgileri

Dergi Theriogenology
ISSN0093691X
Yayın TarihiTemmuz 2019
Cilt / Sayfa132 · 201-211
DOI10.1016/j.theriogenology.2019.04.015
Scopus ID2-s2.0-85064634428
Özet Cancer is a major public health problem, young cancer patients therefore undergo chemotherapy, and most of them may lose their fertility. DNA damage level provides important clues about the quality and reproductive potential of spermatozoa. In this study, we evaluated the levels of both DNA fragmentation and abnormal DNA integrity in the epididymal sperms of New Zealand rabbit (Oryctolagus cuniculus) after cryopreservation using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay and the toluidine blue (TB) staining methods and assessed the effects of paclitaxel, resveratrol, L-glutamine (LG), and basal medium eagle (BME) solution on DNA damage. Paclitaxel induced the levels of both DNA damages in the sperms, but resveratrol ameliorated this effect. LG and BME supplementation to the extender prevented the sperm samples from DNA fragmentation after cryopreservation. Chemotherapy drugs containing paclitaxel can cause the sperm DNA to be damaged, and hence adversely affect the fertility of male cancer patients of reproductive age. The administration of resveratrol together with paclitaxel may ameliorate the DNA damage inducing effect of paclitaxel. Sperm banking and cryopreservation with the appropriate cryoprotectants such as LG and BME prior to cancer treatment can also be suggested to all male cancer patients of reproductive age facing cancer treatment for fertility preservation.

Yazarlar (6)

1
Pinar Ili
2
Fikret Sari
3
Mustafa Numan Bucak
4
Caner Ozturk
5
Şükrü Güngör
6
M. B. Ataman

Anahtar Kelimeler

Cancer Cryopreservation DNA damage Fertility Paclitaxel Resveratrol

Kurumlar

Aksaray Üniversitesi
Aksaray Turkey
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Pamukkale Üniversitesi
Denizli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Theriogenology
Q1
SJR Skoru0,780
H-Index160
YayıncıElsevier Inc.
ÜlkeUnited States
Animal Science and Zoology (Q1)
Equine (Q1)
Food Animals (Q1)
Small Animals (Q1)
Dergi sayfasına git

Metrikler

17
Atıf
6
Yazar
6
Anahtar Kelime

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