Scopus
YÖKSİS Eşleşti
Bismuthene nanosheets as a photodynamic and photothermal antibacterial agent under NIR light illumination
Journal of Environmental Chemical Engineering · Ekim 2024
YÖKSİS Kayıtları
Bismuthene nanosheets as a photodynamic and photothermal antibacterial agent under NIR light illumination
Journal of Environmental Chemical Engineering · 2024 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ İLKNUR AKSOY ÇEKCEOĞLU →
Bismuthene nanosheets as a photodynamic and photothermal antibacterial agent under NIR light illumination
Journal of Environmental Chemical Engineering · 2024 SCI-Expanded
PROFESÖR İMREN HATAY PATIR →
Makale Bilgileri
DergiJournal of Environmental Chemical Engineering
Yayın TarihiEkim 2024
Cilt / Sayfa12
Scopus ID2-s2.0-85198556340
Özet
Bacterial infections remain a significant public health burden due to the emergence of antibiotic resistance and their non-specific cytotoxic effects, leading to the search for novel antibacterial agents. Two-dimensional (2D) pnictogens, which stand out with their advantegeous properties such as large surface areas, compatibility with biological systems, and permeability across biological membranes, have emerged as potential materials in the fight against bacterial infections. By considering all these advantages, here for the first time, the antibacterial activity of 2D bismuth (Bismuthene, Biene) on Gram-negative Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), Gram-positive Staphylococcus aureus (S. aureus) and Methicillin-Resistant Staphylococcus aureus (MRSA) were examined under NIR light illumination. A growth curve analysis was conducted with a concentration of 256 μg*mL−1 of exfoliated Biene nanosheets to assess the inhibition effect and corresponding antibacterial effect (%) against each bacterial strain. The photodynamic theraphy (PDT) and photothermal therapy (PTT)-mediated antibacterial mechanisms were explored by analyzing the generation of reactive oxygen species (ROS) via Glutathione (GSH) oxidation assay while a photothermal camera monitored temperature dynamic changes during irradiation. The high specific surface area-dependent membrane damage ability of Biene and morphological changes of the bacteria were visualized by field emission scanning electron microscope (FESEM). The exciting growth inhibition activity of Biene nanosheets for all bacterial strains was increased during irradiation, and breathtakingly the inhibition rate reached up to ≥ 99.1 % for P. aeruginosa, S. aureus, and MRSA. Besides, S. aureus and MRSA are more susceptible to Biene than E. coli and P. aeruginosa.
Yazarlar (5)
1
Zafer Eroğlu
ORCID: 0000-0002-0601-2526
2
İlknur Aksoy Çekceoğlu
ORCID: 0000-0001-9950-3967
3
Temirlan Kubanaliev
4
Imren Hatay Patir
ORCID: 0000-0003-2937-6557
5
Önder Metin
ORCID: 0000-0003-1622-4992
Anahtar Kelimeler
Antibacterial agents
Bismuthene
Photodynamic effect
Photothermal effect
Reactive oxygen species
Kurumlar
Koç Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey