Scopus
YÖKSİS Eşleşti
The Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish population
Gene · Ocak 2014
YÖKSİS Kayıtları
The Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish population
Gene · 2014 SCI-Expanded
DOÇENT HÜLYA ÖZDEMİR →
Makale Bilgileri
DergiGene
Yayın TarihiOcak 2014
Cilt / Sayfa534 · 10-16
Scopus ID2-s2.0-84888037570
Özet
Adiponectin, an adipose tissue specific protein encoded by the Adiponectin gene, modulates insulin sensitivity and plays an important role in regulating energy homeostasis. Many studies have shown that single nucleotide polymorphisms (SNPs) in the Adiponectin gene are associated with low plasma Adiponectin levels, insulin resistance and an increased risk of type 2 diabetes mellitus. The aim of the present study was to evaluate the contribution of the Adiponectin gene polymorphisms in genetic background of type 2 diabetes in a Turkish population. In total, 169 unrelated and non-obese diabetic patients and 119 age- and BMI-matched non-diabetic individuals with no family history of diabetes were enrolled in this study. We detected a significant association between type 2 diabetes and two SNPs: SNP -11391G. >. A, which is located in the promoter region of the Adiponectin gene, and SNP +. 276G. >. T, which is found in intron 2 of the gene (P<. 0.05). The silence SNP G15G (+. 45T. >. G) in exon 1 and SNP +. 349A. >. G in intron 2 also showed a weak association with type 2 diabetes (P= 0.06 and P= 0.07, respectively), while SNPs -3971A. >. G in intron 1 and Y111H, R112C and H241P in exon 3 showed no association (P>. 0.05). In conclusion, these findings suggest that Adiponectin gene polymorphisms might be effective on susceptibility for type 2 diabetes development which emerged from the interactions between multiple genes, variants and environmental factors. © 2013 Elsevier B.V.
Yazarlar (7)
1
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
2
Hulya Ozdemir
3
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
4
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
5
Ahmet Arslan
6
Seyit Ali Kayis
7
Mustafa Sait Gonen
Anahtar Kelimeler
Adiponectin gene
Single nucleotide polymorphism
Type 2 diabetes
Kurumlar
Gaziantep Üniversitesi
Gaziantep Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
24
Atıf
7
Yazar
3
Anahtar Kelime