Scopus
🔓 Açık Erişim
IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population
Meta Gene · Aralık 2014
Makale Bilgileri
DergiMeta Gene
Yayın TarihiAralık 2014
Cilt / Sayfa2 · 579-585
Scopus ID2-s2.0-84916210482
Erişim🔓 Açık Erişim
Özet
Insulin receptor substrate 1 (IRS1), plays a critical role in insulin signaling and its control has an important place in the development of insulin resistance. The tyrosine phosphorylation of IRS1 serves as docking molecules for downstream effectors such as Phosphatidylinositol 3-kinase and phosphotyrosine phosphatase-2. We focused on the Gly972Arg and Ala513Pro variants of the IRS1 gene, since these specific allelic variants are located near the Tyr-Met-X-Met (YMXM) motifs around Tyr987 and Tyr612. Thus, we aimed to investigate the effects of Gly972Arg/Ala513Pro polymorphisms in IRS1 gene on development of insulin resistance and the risk of type 2 diabetes in a non-obese Turkish population. This work included 306 individuals comprising 178 subjects with type 2 diabetes and 128 healthy subjects matched for body mass index. Gly972Arg/Ala513Pro polymorphisms had no effect on type 2 diabetes risk and its phenotypes (P. > 0.05). Although IRS1 gene and its variants are associated with type 2 diabetes and insulin resistance in several studies worldwide, our data showed that there is no association between Gly972Arg and Ala513Pro variants in IRS1 and disease in Turkish population.
Yazarlar (6)
1
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
2
Melda Aksoy Hepdogru
3
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
4
Aycan Asik
5
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
6
Funda Iscioglu
Anahtar Kelimeler
I˙nsulin resistance
IRS1 gene
Polymorphisms
Type 2 diabetes
Kurumlar
Ege Üniversitesi
Izmir Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
25
Atıf
6
Yazar
4
Anahtar Kelime