Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictors of type 2 diabetes among nonobese diabetics in the Turkish population
Turkish Journal of Medical Sciences · Ocak 2017
YÖKSİS Kayıtları
The transcription factor 7 like 2 TCF7L2 gene polymorphisms are strong predictors of type 2 diabetes among non obese diabetics in the Turkish population
Turkish Journal Of Medical Sciences · 2016 SCI-Expanded
Doç. Dr. DUDU ERKOÇ KAYA →
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Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
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Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
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2016 ISSN: 1300-0144 SCI-Expanded
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Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2017
Cilt / Sayfa47 · 22-28
Scopus ID2-s2.0-85014088061
Erişim🔓 Açık Erişim
Özet
Background/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods: Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results: We found that rs7903146 C → T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G → T substitution in intron 4 (OR: 2.1, P = 0.002) were significantly associated with T2D while other SNPs were not associated (P > 0.05). We determined no association between TCF7L2 gene polymorphisms and fasting glucose, fasting insulin, HbA1c, or HOMA-IR levels (P > 0.05), except for rs7903146 C → T substitution, which was significantly associated with the fasting glucose level (P = 0.003). Conclusion: Our results indicate that, in the Turkish population, the T allele of the rs7903146 (C → T) and rs12255372 (G → T) polymorphisms in the TCF7L2 gene is an independent risk factor for the development of T2D.
Yazarlar (5)
1
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
2
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
3
Seyit Ali Kayis
4
Onur Öztürk
5
Mustafa Sait Gonen
Anahtar Kelimeler
Single nucleotide polymorphism
TCF7L2 gene
Type 2 diabetes mellitus
Wnt pathway
Kurumlar
Demiroglu Bilim University
Istanbul Turkey
Inönü Üniversitesi
Malatya Turkey
Karabük Üniversitesi
Karabuk Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
16
Atıf
5
Yazar
4
Anahtar Kelime