Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling
Bratislava Medical Journal · Ocak 2021
YÖKSİS Kayıtları
Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling
Bratislava Medical Journal · 2021 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ FATMA GÖKTÜRK →
Juglone can inhibit angiogenesis and metastasis in pancreatic cancer cells by targeting Wnt/β-catenin signaling
Bratislava Medical Journal · 2021 SCI-Expanded
PROFESÖR HİLAL ARIKOĞLU →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2021
Cilt / Sayfa122 · 132-137
Scopus ID2-s2.0-85100602122
Erişim🔓 Açık Erişim
Özet
OBJECTIVES: We aimed to investigate the effects of juglone on angiogenesis, metastasis and cell proliferation processes in pancreatic cancer (PC) and to understand whether its possible effects occur via the Wnt signaling pathway by analyzing the expression levels of target genes of Wnt signaling. BACKGROUND: PC is a silent and lethal cancer type which can only be detectable after metastasis and angiogenesis processes occured. The Wnt signaling pathway is one of the pathways that plays an active role in many biological processes in the cell. Mutations in the genes of this signaling pathway are related to the development of many cancers. Juglone, a natural compound, is shown to have cytotoxic and apoptotic effects on various cancer cells. METHODS: PANC-1 and BxPC-3 pancreatic cancer cells were treated with juglone at < IC50 doses (5, 10,15, and 20 μM) for 24 h. Expression levels of MMP7, VEGF, TCF7L2, CCND1 genes were determined by RT-PCR. Cell migration evaluation after juglone treatments were done by a wound-healing assay. RESULTS: Juglone seems to be able to inhibit angiogenesis and metastasis by affecting the activity of Wnt signaling target genes in human PC cell lines. CONCLUSION: Juglone has a promising potential to develop new strategies for the treatment of PC (Tab. 2, Fig. 4, Ref. 35). Text in PDF www.elis.sk
Yazarlar (3)
1
Fatma Gokturk
2
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
3
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
Anahtar Kelimeler
anoikis
juglone
pancreatic cancer
Wnt signaling pathway
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
15
Atıf
3
Yazar
4
Anahtar Kelime