Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Health Sciences · Ocak 2022
YÖKSİS Kayıtları
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ DUYGU DURSUNOĞLU →
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
PROFESÖR HİLAL ARIKOĞLU →
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
DOÇENT DUDU ERKOÇ KAYA →
Makale Bilgileri
DergiAfrican Health Sciences
Yayın TarihiOcak 2022
Cilt / Sayfa22 · 334-342
Scopus ID2-s2.0-85135330762
Erişim🔓 Açık Erişim
Özet
Background: Pancreatic cancer does not show any symptoms in the early period and metastatic process is already passed when the diagnosis is done. Therefore, in the battle with pancreatic cancer, novel treatment strategies, particularly antiinva-sive and antimetastatic strategies, are needed. The cytotoxic and anticancer effects of juglone and sodium selenite (NaSe) have been showed in various cancer cells. Objectives: In this study, it is aimed to investigate the synergistic effects of juglone and selenium on PANC-1 and BxPC-3 pancreatic cancer cells. Methods: Antimetastatic effects of juglone-NaSe were carried out by adhesion and invasion assays and the genes and protein expressions. Expression analysis of the CDH1, ITGB3 and COL4A3 genes and their proteins E-cadherin, β3 integrin and tumstatin which play role in metastasis and angiogenesis processes, were done by qPCR and immunohistochemical analysis, respectively. Results: Study findings have provided evidences that the juglone-selenium has a cytotoxic and dose dependent suppressive effect on invasion and metastasis in PANC-1 and BxPC-3 cells. Conclusion: The juglone-NaSe has the potential to be a promising agent especially to inhibit invasion and metastasis in pancreatic cancer treatment. However, more in depth studies are needed to more clearly demonstrate the effects of juglone-se-lenium.
Yazarlar (4)
1
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
2
Duygu Dursunoǧlu
ORCID: 0000-0003-4414-8659
3
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
4
Ebru Avci
Anahtar Kelimeler
invasion
juglone-selenium
metastasis
Pancreatic cancer cell lines
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
4
Yazar
4
Anahtar Kelime