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The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines

African Health Sciences · Ocak 2022

YÖKSİS DOI Eşleşmesi Bulundu

Bu Scopus makalesi YÖKSİS veritabanında da kayıtlı. Aşağıda YÖKSİS verilerini görebilirsiniz.

YÖKSİS Kayıtları
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
Doç. Dr. DUDU ERKOÇ KAYA →
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
Dr. Öğr. Üyesi DUYGU DURSUNOĞLU →
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
African Journals Online (AJOL) · 2022 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 11 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
The effect of obesity on metabolic parameters: a cross sectional study in adult women
2022 ISSN: 1680-6905 SCI-Expanded Q3
Dr. Öğr. Üyesi SEYİT RAMAZAN KARADOĞAN →
The effects of Juglone-Selenium combination on invasion and metastasis in pancreatic cancer cell lines
2022 ISSN: 1680-6905 SCI-Expanded Q2
Prof. Dr. HİLAL ARIKOĞLU →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloprotein- ase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded Q4
Prof. Dr. HÜSAMETTİN VATANSEV →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded Q2
Prof. Dr. NAZLIM AKTUĞ DEMİR →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded Q4
Prof. Dr. ŞUA SÜMER →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded Q4
Prof. Dr. ONUR URAL →
Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve
2021 ISSN: 1680-6905 SCI-Expanded
Dr. Öğr. Üyesi YASİN ÖZEN →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase-1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded Q4
Doç. Dr. HAKAN CEBECİ →
An evaluation of matrix metalloproteinase-9 (Mmp-9) and tissue inhibitor metalloproteinase- 1 (Timp-1) Serum levels and the Mmp-9/Timp-1 Ratio in Covid-19 patients
2023 ISSN: 1680-6905 SCI-Expanded
Prof. Dr. UĞUR ARSLAN →
Mean Platelet volume in diagnosis of acute appendicitis in children
2011 ISSN: 1680-6905 SCI-Expanded
Prof. Dr. TAMER SEKMENLİ →
Possible link between Toxoplasma gondii and neurodegenerative diseases
2025 ISSN: 1680-6905 SCI-Expanded
Dr. Öğr. Üyesi NERİMAN AKDAM →

Makale Bilgileri

Dergi African Health Sciences
ISSN16806905
Yayın TarihiOcak 2022
Cilt / Sayfa22 · 334-342
DOI10.4314/ahs.v22i2.37
Scopus ID2-s2.0-85135330762
Erişim🔓 Açık Erişim
Özet Background: Pancreatic cancer does not show any symptoms in the early period and metastatic process is already passed when the diagnosis is done. Therefore, in the battle with pancreatic cancer, novel treatment strategies, particularly antiinva-sive and antimetastatic strategies, are needed. The cytotoxic and anticancer effects of juglone and sodium selenite (NaSe) have been showed in various cancer cells. Objectives: In this study, it is aimed to investigate the synergistic effects of juglone and selenium on PANC-1 and BxPC-3 pancreatic cancer cells. Methods: Antimetastatic effects of juglone-NaSe were carried out by adhesion and invasion assays and the genes and protein expressions. Expression analysis of the CDH1, ITGB3 and COL4A3 genes and their proteins E-cadherin, β3 integrin and tumstatin which play role in metastasis and angiogenesis processes, were done by qPCR and immunohistochemical analysis, respectively. Results: Study findings have provided evidences that the juglone-selenium has a cytotoxic and dose dependent suppressive effect on invasion and metastasis in PANC-1 and BxPC-3 cells. Conclusion: The juglone-NaSe has the potential to be a promising agent especially to inhibit invasion and metastasis in pancreatic cancer treatment. However, more in depth studies are needed to more clearly demonstrate the effects of juglone-se-lenium.

Yazarlar (4)

1
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
2
Duygu Dursunoǧlu
ORCID: 0000-0003-4414-8659
3
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
4
Ebru Avci

Anahtar Kelimeler

invasion juglone-selenium metastasis Pancreatic cancer cell lines

Kurumlar

Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
African Health Sciences
Q3 OA
SJR Skoru0,370
H-Index63
YayıncıMakerere University, Medical School
ÜlkeUganda
Medicine (miscellaneous) (Q3)
Dergi sayfasına git

Metrikler

7
Atıf
4
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

DE
DUDU ERKOÇ KAYA
Doç. Dr.

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