Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion
Dental Press Journal of Orthodontics · Ocak 2022
YÖKSİS Kayıtları
Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion
Dental press journal of orthodontics · 2022 MEDLINE, İNDEX MEDİCUS
Prof. Dr. ZEHRA İLERİ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effects of teriparatide on bone formation in rats with experimentally induced premaxillary expansion
2022 ISSN: 2176-9451 MEDLINE, İNDEX MEDİCUS
Prof. Dr. ZEHRA İLERİ →
Makale Bilgileri
ISSN21769451
Yayın TarihiOcak 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85133820733
Erişim🔓 Açık Erişim
Özet
Objective: This study aimed to evaluate the effects of systemic teriparatide on sutural bone formation after premaxillary suture expansion in rats. Material and Methods: Twenty Wistar male rats (8–10 weeks old) were randomly divided into two groups, namely, control (C, n=10) and teriparatide (T, n=10). An expansion force was ap-plied to the maxillary incisors using helical spring for a sev-en-day expansion period, for both groups. On the eighth day, the rats were kept for a seven-day consolidation period, and then 60 µg/kg teriparatide (once a day) was administered to group T subcutaneously for seven days. Then, all the rats were sacrificed, and histological sections were stained with hemo-toxylin-eosin for examination. Anti-osteonectin, anti-osteo-calcin, anti-Vascular endothelial growth factor (VEGF) and an-ti-transforming growth factor beta (TGF-β) were evaluated by immunohistochemical analysis in the midpalatal suture area. Results: Histologically, the newly formed bone tissue was observed to be larger in group T than in group C. The number of immunoreactive osteoblasts for osteonectin, osteocalcin and VEGF antibodies was significantly higher in group T than in group C (p = 0.0001). The TGF-β antibody showed a mild reac-tion in group T, but did not reach significance in comparison with group C (p ˃ 0.05). Conclusion: Systemic teriparatide application following the premaxillary expansion of the suture area may stimulate bone formation and add to the consolidation of the expansion in rats by regulating osteonectin, osteocalcin and VEGF.
Yazarlar (5)
1
Yasin Çamili
ORCID: 0000-0002-1544-0821
2
Sıddık Malkoç
3
Aslı Taşlidere
ORCID: 0000-0003-3902-3210
4
Zehra Ileri
5
Ozge Celik Guler
ORCID: 0000-0003-3276-2408
Anahtar Kelimeler
Maxillary expansion
Osteocalcin
Osteonectin
Teriparatide
TGF-β
Kurumlar
Çanakkale Onsekiz Mart Üniversitesi
Canakkale Turkey
Inönü Üniversitesi Tip Fakültesi
Malatya Turkey
Private Practice
Balikesir Turkey
Private Practice
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Dental Press Journal of Orthodontics
Q1
OA
SJR Skoru0,604
H-Index42
YayıncıDental Press International
ÜlkeBrazil
Oral Surgery (Q1)
Orthodontics (Q1)
Metrikler
5
Atıf
5
Yazar
5
Anahtar Kelime