Scopus
🔓 Açık Erişim
Chemical investigation and bioactivity screening of Salvia cassia extracts
Records of Natural Products · Ocak 2019
Makale Bilgileri
DergiRecords of Natural Products
Yayın TarihiOcak 2019
Cilt / Sayfa13 · 156-166
Scopus ID2-s2.0-85058060670
Erişim🔓 Açık Erişim
Özet
In this study the antioxidant and anticholinesterase activities of the crude ethanol extract, as well as the dichloromethane and water extracts obtained from partitioning of the crude ethanol extract, of the plant Salvia cassia Samuelss ex. Rech. Fil, were determined. The extracts were screened for their total phenolic and flavonoid contents. The dichloromethane extract, which showed higher inhibition of lipid peroxidation, higher metal chelating capacity and also a higher flavonoid content than the other extracts was analyzed for its constituents. GC-MS analysis resulted in the identification of a total of 30 long chain hydrocarbons. A series of β-amyrin fatty acid esters, a triterpene acid oleanolic acid, a diterpenoid manoyloxide, and two flavonoids apigenin 7, 4′-dimethyl ether and salvigenin were isolated by open column chromatography. Their structures were identified based on NMR and mass spectrometric techniques. The isolated compounds were also tested for their anticholinesterase activities. The triterpenoids as well as the water extract exhibited promising anticholinesterase activity.
Yazarlar (4)
1
Belkıs Halfon
ORCID: 0000-0001-5845-5081
2
Özlem Çetin
ORCID: 0000-0003-2886-3409
3
Gamze Kökdil
ORCID: 0000-0001-8832-4322
4
Gulacti Topcu
Anahtar Kelimeler
Anticholinesterase activity
Antioxidant activity
Fatty acid composition
Flavonoids
Salvia cassia
β-amyrin fatty acid esters
Kurumlar
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Boğaziçi Üniversitesi
Bebek Turkey
Mersin Üniversitesi
Mersin Turkey
Metrikler
12
Atıf
4
Yazar
6
Anahtar Kelime