Scopus
YÖKSİS Eşleşti
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)
Neurobiology of Aging · Haziran 2017
YÖKSİS Kayıtları
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)
NEUROBIOLOGY OF AGING · 2017 SCI
DOKTOR ÖĞRETİM ÜYESİ ELİF TUĞCE KAROĞLU ERAVŞAR →
Makale Bilgileri
DergiNeurobiology of Aging
Yayın TarihiHaziran 2017
Cilt / Sayfa54 · 10-21
Scopus ID2-s2.0-85015069737
Özet
The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The current study tested the hypothesis of an association between brain aging and synaptic protein loss across males and females. Western blot analysis of synaptophysin (SYP), a presynaptic vesicle protein, and postsynaptic density-95 (PSD-95) and gephyrin (GEP), excitatory and inhibitory postsynaptic receptor-clustering proteins, respectively, was performed in young, middle-aged, and old male and female zebrafish (Danio rerio) brains. Univariate and multivariate analyses demonstrated that PSD-95 significantly increased in aged females and SYP significantly decreased in males, but GEP was stable. Thus, these key synaptic proteins vary across age in a sexually dimorphic manner, which has been observed in other species, and these consequences may represent selective vulnerabilities for aged males and females. These data expand our knowledge of normal aging in zebrafish, as well as further establish this model as an appropriate one for examining human brain aging.
Yazarlar (7)
1
Elif Tugce Karoglu-Eravsar
2
Dilara Ozge Halim
3
Bahriye Erkaya
4
Ferda Altaytas
5
Ayca Arslan-Ergul
6
Ozlen Konu
7
Michelle M. Adams
Anahtar Kelimeler
Aging
Excitatory synapses
Gender
Inhibitory synapses
Synaptic proteins
Zebrafish
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Metrikler
18
Atıf
7
Yazar
6
Anahtar Kelime