Scopus
YÖKSİS Eşleşti
The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system
Neurobiology of Aging · Şubat 2021
YÖKSİS Kayıtları
The optomotor response of aging zebrafish reveals a complex relationship between visual motion characteristics and cholinergic system
Neurobiology of Aging · 2021 SCI-Expanded
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Makale Bilgileri
DergiNeurobiology of Aging
Yayın TarihiŞubat 2021
Cilt / Sayfa98 · 21-32
Scopus ID2-s2.0-85096382039
Özet
Understanding the principles underlying age-related changes in motion perception is paramount for improving the quality of life and health of older adults. However, the mechanisms underlying age-related alterations in this aspect of vision, which is essential for survival in a dynamic world, still remain unclear. Using optomotor responses to drifting gratings, we investigated age-related changes in motion detection of adult zebrafish (wild-type/AB-strain and achesb55/+ mutants with decreased levels of acetylcholinesterase). Our results pointed out negative optomotor responses that significantly depend on the spatial frequency and contrast level of stimulation, providing supporting evidence for the visual motion-driven aspect of this behavior mainly exhibited by adult zebrafish. Although there were no significant main effects of age and genotype, we found a significant three-way interaction between contrast level, age, and genotype. In the contrast domain, the changes in optomotor responses and thus in the detection of motion direction were age- and genotype-specific. Accordingly, these behavioral findings suggest a strong but complicated relationship between visual motion characteristics and the cholinergic system during neural aging.
Yazarlar (6)
1
Aysenur Karaduman
2
Elif Tugce Karoglu-Eravsar
3
Utku Kaya
4
Alaz Aydin
5
Michelle M. Adams
6
Hulusi Kafaligonul
ORCID: 0000-0001-5033-4138
Anahtar Kelimeler
Acetylcholine
Aging
Direction
Motion detection
Zebrafish
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Metrikler
8
Atıf
6
Yazar
5
Anahtar Kelime