Scopus
YÖKSİS Eşleşti
Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system
Neurobiology of Aging · Ekim 2023
YÖKSİS Kayıtları
Zebrafish optomotor response to second-order motion illustrates that age-related changes in motion detection depend on the activated motion system.
Neurobiology of aging · 2023 SCI-Expanded
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Makale Bilgileri
DergiNeurobiology of Aging
Yayın TarihiEkim 2023
Cilt / Sayfa130 · 12-21
Scopus ID2-s2.0-85164327460
Özet
Various aspects of visual functioning, including motion perception, change with age. Yet, there is a lack of comprehensive understanding of age-related alterations at different stages of motion processing and in each motion system. To understand the effects of aging on second-order motion processing, we investigated optomotor responses (OMR) in younger and older wild-type (AB-strain) and acetylcholinesterase (achesb55/+) mutant zebrafish. The mutant fish with decreased levels of acetylcholinesterase have been shown to have delayed age-related cognitive decline. Compared to previous results on first-order motion, we found distinct changes in OMR to second-order motion. The polarity of OMR was dependent on age, such that second-order stimulation led to mainly negative OMR in the younger group while older zebrafish had positive responses. Hence, these findings revealed an overall aging effect on the detection of second-order motion. Moreover, neither the genotype of zebrafish nor the spatial frequency of motion significantly changed the response magnitude. Our findings support the view that age-related changes in motion detection depend on the activated motion system.
Yazarlar (6)
1
Aysenur Karaduman
2
Elif Tugce Karoglu-Eravsar
3
Utku Kaya
4
Alaz Aydin
5
Michelle M. Adams
6
Hulusi Kafaligonul
ORCID: 0000-0001-5033-4138
Anahtar Kelimeler
Acetylcholinesterase
Aging
Motion detection
Second-order motion
Zebrafish
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Middle East Technical University (METU)
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Michigan Medical School
Ann Arbor United States
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime