Scopus
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Long-Term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain
Gerontology · Aralık 2023
YÖKSİS Kayıtları
Long-Term Acetylcholinesterase Depletion Alters the Levels of Key Synaptic Proteins while Maintaining Neuronal Markers in the Aging Zebrafish (Danio rerio) Brain.
Gerontology · 2023 SCI-Expanded
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Makale Bilgileri
DergiGerontology
Yayın TarihiAralık 2023
Cilt / Sayfa69 · 1424-1436
Scopus ID2-s2.0-85178566544
Erişim🔓 Açık Erişim
Özet
Introduction: Interventions targeting cholinergic neurotransmission like acetylcholinesterase (AChE) inhibition distinguish potential mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were assessed within the context of aging and chronic reduction of AChE activity. Long-term depletion of AChE activity was induced by using a mutant zebrafish line, and they were compared with the wildtype group at young and old ages. Results: Results demonstrated that AChE activity was lower in both young and old mutants, and this decrease coincided with a reduction in ACh content. Additionally, an overall age-related reduction in AChE activity and the AChE/ACh ratio was observed, and this decline was more prominent in wildtype groups. The levels of an immature neuronal marker were upregulated in mutants, while a glial marker showed an overall reduction. Mutants had preserved levels of inhibitory and presynaptic elements with aging, whereas glutamate receptor subunit levels declined. Conclusion: Long-term AChE activity depletion induces synaptic and cellular alterations. These data provide further insights into molecular targets and adaptive responses following the long-term reduction of AChE activity that was also targeted pharmacologically to treat neurodegenerative diseases in human subjects.
Yazarlar (8)
1
Elif Tugce Karoglu-Eravsar
2
Melek Umay Tuz-Sasik
3
Aysenur Karaduman
4
Ayse Gokce Keskus
5
Ayca Arslan-Ergul
6
Ozlen Konu
7
Hulusi Kafaligonul
ORCID: 0000-0001-5033-4138
8
Michelle M. Adams
Anahtar Kelimeler
Acetylcholinesterase
Aging
Cholinergic system
Neuronal changes
Synapses
Kurumlar
Bilkent Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
8
Yazar
5
Anahtar Kelime