Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Detection of botulinum neurotoxin serotypes c and d, and their effects on expressions of snap-25 and synaptobrevin in ruminants: An immunohistochemical study[1,2]
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2021
YÖKSİS Kayıtları
Detection of Botulinum Neurotoxin Serotypes C and D, and Their Effects on Expressions of SNAP-25 and Synaptobrevin in Ruminants: An Immunohistochemical Study (Ruminantlarda Botulinum Nörotoksin Serotip C ve D\u2019nin Saptanması ve bunların SNAP ve Sinaptobrevin Ekspresyonları Üzerindeki Etkileri: İmmunohistokimyasal Bir Çalışma)
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2021 TR-DİZİN, CABI, EBSCO, Scobus
Prof. Dr. MUSTAFA ORTATATLI →
Ruminantlarda Botulinum Nörotoksin Serotip C ve D'nin Saptanması ve bunların SNAP ve Sinaptobrevin Ekspresyonları Üzerindeki Etkileri: İmmunohistokimyasal Bir Çalışma
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2021 SCI-Expanded
Arş. Gör. ZEYNEP ÇELİK KENAR →
Detection of Botulinum Neurotoxin Serotypes C and D, and Their Effects on Expressions of SNAP-25 and Synaptobrevin in Ruminants: An Immunohistochemical Study (Ruminantlarda Botulinum Nörotoksin Serotip C ve D\u2019nin Saptanması ve bunların SNAP ve Sinaptobrevin Ekspresyonları Üzerindeki Etkileri: İmmunohistokimyasal Bir Çalışma)
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2021 TR-DİZİN, CABI, EBSCO, Scobus
Arş. Gör. ZEYNEP ÇELİK KENAR →
Ruminantlarda Botulinum Nörotoksin Serotip C ve D'nin Saptanması ve bunların SNAP ve Sinaptobrevin Ekspresyonları Üzerindeki Etkileri: İmmunohistokimyasal Bir Çalışma
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2021 SCI-Expanded
Doç. Dr. MEHMET BURAK ATEŞ →
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İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
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Etanersept endotoksemi tedavisinde kullanılabilir mi
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Makale Bilgileri
ISSN13006045
Yayın TarihiOcak 2021
Cilt / Sayfa27 · 191-201
Scopus ID2-s2.0-85101739872
Erişim🔓 Açık Erişim
Özet
In humans and animals, botulism is a disease characterized by generalized and progressive paralysis caused by Clostridium botulinum neurotoxins (BoNT). BoNTs, defined in seven different antigenic types (A to G), proteolyze SNAREs (synaptosomal-associated protein/SNAP-25 and synaptobrevin) responsible for acetylcholine release in peripheral cholinergic neurons, and thus cause flaccid paralysis and death. Currently, mouse experiments are considered the reference method for definitive diagnosis. However, new diagnostic methods that are fast and accurate and would not raise ethical issues need to be developed. Therefore, using antibodies specific to the toxoid forms of BoNTs, the presence of BoNT-C and/or BoNT-D was investigated by immunohistochemical method (IHC) in the study. The tissues of thirty ruminants (twenty cattle, seven sheep, three goats), which had the clinical and pathological findings of botulism and a herd history of the disease, were used as material. BoNTs were detected with IHC in sixteen of the thirty ruminants as three BoNT-C, eleven BoNT-D, and two BoNT C+D. In the mouse experiments, BoNT was isolated in only three cases (two BoNT-D, one BoNT-C). Additionally, being responsible for the clinical findings of botulism, the interaction of BoNTs with SNAP-25 and synaptobrevin was investigated using IHC. It was determined that BoNT-C specifically reduces the expression of SNAP-25, and BoNT-D reduces the expression of synaptobrevin and partially SNAP-25. It was concluded that additional studies may be valuable to investigate the use of IHC in the diagnosis of botulism.
Yazarlar (5)
1
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
2
Funda Terzi
ORCID: 0000-0002-6184-5408
3
Mustafa Kemal Çiftçi
4
M. Ortatatli
5
Zeynep Celik
ORCID: 0000-0002-9667-5728
Anahtar Kelimeler
BoNT-C
BoNT-D
Immunohistochemistry
SNAP-25
Synaptobrevin
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)