Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
Drug and Chemical Toxicology · Ocak 2023
YÖKSİS Kayıtları
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
Drug and Chemical Toxicology · 2023 SCI-Expanded
Doç. Dr. MEHMET BURAK ATEŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Assessment of Antimutagenic Action of Celtis glabrata Steven ex Planch Cannabaceae Extracts Against Base Pair Exchange and Frame Shift Mutations on Salmonella typhimurium TA98 and TA100 Strains by Ames Test
2016 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs
2012 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SCI-Expanded
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SSCI
Prof. Dr. MUSTAFA ONUR ALADAĞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q3
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. HASAN ACAR →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
2023 ISSN: 0148-0545 SCI-Expanded Q2
Doç. Dr. MEHMET BURAK ATEŞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. NADİRE ÜNVER DOĞAN →
The neuroprotective effect of 1,25-dyhydroxyvitamin D3 (calcitriol) and probiotics on the rotenone-induced neurotoxicity model in SH-SY5Y cells
2025 ISSN: 0148-0545 SCI-Expanded Q3
Dr. Öğr. Üyesi FATMA HAZAN DOĞAN →
Makale Bilgileri
ISSN01480545
Yayın TarihiOcak 2023
Cilt / Sayfa46 · 566-574
Scopus ID2-s2.0-85132651137
Özet
Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen (APAP) induced hepatotoxicity is still unknown. Thus, we aimed to investigate the lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on APAP-induced hepatotoxicity in mice. Hepatotoxicity was induced by a single injection of APAP (300 mg/kg, intraperitoneally). Isorhamnetin (50 or 100 mg/kg, orally) and N-acetylcysteine (NAC) (200 mg/kg, orally), or vehicle control, were administered 1 h before the administration of APAP. Total antioxidant status (TAS) and total oxidative status (TOS) of liver tissue and levels of inflammatory factors (TNF-α, IL-1β, and IL-6) were analyzed by ELISA. Lipid profiles and liver function parameters were measured using an autoanalyzer. In addition, liver tissue was examined histopathologically. Isorhamnetin treatment significantly reduced the APAP-induced increase in the liver weight and liver index; it also reduced the APAP-induced increase in serum liver parameters (ALT, AST, ALP, and LDH) (p < 0.05). Isorhamnetin significantly reduced APAP-induced oxidative stress and inflammation by increasing TAS levels and decreasing TOS, TNF-α, IL-1β, and IL-6 levels (p < 0.05). Moreover, isorhamnetin treatment significantly regulated lipid profiles (TG, T-C, LDL-C, and HDL-C levels) that changed in response to APAP administration (p < 0.05). In histopathological examination, liver degeneration observed in the APAP group was significantly reduced in the NAC and isorhamnetin-treated groups (p < 0.05). This study suggests that isorhamnetin has a significant protective effect on APAP-induced hepatotoxicity in mice through its lipid-lowering, antioxidant, and anti-inflammatory effects.
Yazarlar (3)
1
Huseyin Gungor
ORCID: 0000-0002-2506-3855
2
Mehmet Ekici
ORCID: 0000-0002-2163-6214
3
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
Anahtar Kelimeler
acetaminophen
hepatotoxicity
Isorhamnetin
mice
N-acetylcysteine
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Drug and Chemical Toxicology
Q2
SJR Skoru0,535
H-Index60
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Public Health, Environmental and Occupational Health (Q2)
Chemical Health and Safety (Q3)
Health, Toxicology and Mutagenesis (Q3)
Pharmacology (Q3)
Toxicology (Q3)
Metrikler
22
Atıf
3
Yazar
5
Anahtar Kelime