Scopus
YÖKSİS Eşleşti
Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats
Biotechnic and Histochemistry · Ocak 2024
YÖKSİS Kayıtları
Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats
Biotechnic & Histochemistry · 2024 SCI-Expanded
PROFESÖR ÖZGÜR ÖZDEMİR →
Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats
Biotechnic & Histochemistry · 2024 SCOPUS
DOÇENT MEHMET BURAK ATEŞ →
Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats
Biotechnic & Histochemistry · 2024 SCI
PROFESÖR NURİ BAŞPINAR →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiOcak 2024
Scopus ID2-s2.0-85200235208
Özet
Possible protective and therapeutic effects of nobiletin on kidney in a cisplatin-induced nephrotoxicity rat model were investigated. Forty male albino rats were divided into four groups: control, cisplatin (CIS), cisplatin+nobiletin (CIS+NOB), and nobiletin+cisplatin (NOB+CIS). At the end of the study, the rats were subjected to biochemical, histological and immunohistochemical analyzes. Compared to the control group, tGSH (p < 0.05) levels, and G6PD (p < 0.05) and GPx (p < 0.001) activities, were increased in the CIS group; while significant (p < 0.05) decreases occurred in the MDA and TOC levels. Histopathologically, the kidneys of the groups administered nobiletin (CIS+NOB, NOB+CIS) were significantly different from the CIS group, being closer to control group in terms of degeneration and hyaline cylinder formation in the tubules (p < 0.05). While dilatation in the tubules, protein-rich fluid and hyaline cylinder formation in the lumen were most common in the CIS group, a significant decrease (p < 0.05) of these parameters was seen in the nobiletin groups (CIS+NOB, NOB+CIS). This study suggests that nobiletin can be effective in preventing and ameliorating toxic effects of cisplatin on the kidney.
Yazarlar (8)
1
Filiz Kazak
ORCID: 0000-0002-9065-394X
2
P. Coskun
3
Gul Fatma Yarim
4
N. Baspinar
5
O. Ozdemir
6
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
7
Muhammed Enes Altug
8
Mehmet Zeki Yilmaz Deveci
Anahtar Kelimeler
Cisplatin
G6PD
histopathological changes
kidney
nobiletin
Kurumlar
Mustafa Kemal Üniversitesi
Antakya Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey