Scopus
YÖKSİS Eşleşti
Altered methylarginine levels after surgery in subjects with multinodular goiter
Hormone Molecular Biology and Clinical Investigation · Eylül 2021
YÖKSİS Kayıtları
Altered methylarginine levels after surgery in subjects with multinodular goiter
Hormone Molecular Biology and Clinical Investigation · 2021 E-SCI
PROFESÖR ABDULLAH SİVRİKAYA →
Altered methylarginine levels after surgery in subjects with multinodular goiter
Hormone Molecular Biology and Clinical Investigation · 2021 E-SCI
PROFESÖR HÜSNÜ ALPTEKİN →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiEylül 2021
Cilt / Sayfa42 · 291-296
Scopus ID2-s2.0-85101278331
Özet
Objectives: Thyroid disorders are important risk factor for cardiovascular diseases. Levels of methylarginines such as asymmetric dimethyl arginine (ADMA), L-monomethyl arginine (L-NMMA), symmetric dimethyl arginine (SDMA) are increase in cardiovascular diseases. Multinodular goiter (MNG) is the most common type of goiter in adults. To date, no study has been conducted to determine the levels of methylarginine in euthyroid MNG patients. Our aim in this study is to compare levels of methylarginines and related metabolites in the preoperative, postoperative MNG patients and controls. Methods: Serum ADMA, SDMA, L-NMMA, homoarginine (hArg), arginine and citrulline concentrations were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: ADMA (p<0.001), L-NMMA (p=0.002), l-arginine (p=0.006) and citrulline (p<0.001) levels were statistically significantly higher in preop group than postop group. ADMA (p=0.003), L-NMMA (p=0.003) levels were statistically significantly higher and SDMA/ADMA (p<0.001), hArg/ADMA (p<0.001) levels were statistically significantly lower in preop group than control group. Conclusions: The levels of methylarginines and related metabolites altered in the euthyroid MNG patients compared to the control group, and more importantly, there were significant differences between the preop and postop groups. Therefore, these metabolites can be useful in the diagnosis and prognosis of thyroid disorders, even if thyroid hormone levels are normal.
Yazarlar (4)
1
Suheyla Karaman
2
Abdullah Sivrikaya
3
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
4
Husnu Alptekin
Anahtar Kelimeler
cardiovascular diseases
methylarginines
multinodular goiter
thyroid
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey