Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?
American Journal of Reproductive Immunology · Ekim 2021
YÖKSİS Kayıtları
Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?
American Journal of Reproductive Immunology · 2021 SCI-Expanded
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
A Prospective Case-Control Study Analyzes 12 Thrombophilic Gene Mutations in Turkish Couples with Recurrent Pregnancy Loss
2010 ISSN: 10467408 SCI-Expanded
Doç. Dr. NADİR KOÇAK →
Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?
2021 ISSN: 1046-7408 SCI-Expanded Q2
Prof. Dr. FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Comparison of Maternal and Fetal Plasma X Box Binding Protein 1 Levels Between Pregnancies With Fetal Growth Retardation and Healthy Controls
2025 ISSN: 1046-7408 SCI-Expanded Q3
Prof. Dr. ÇETİN ÇELİK →
Makale Bilgileri
ISSN10467408
Yayın TarihiEkim 2021
Cilt / Sayfa86
Scopus ID2-s2.0-85107033097
Özet
Problem: The cesarean section (CS) rate has increased significantly in North America, Western Europe, and Latin America. However, it has been reported that the incidence of inflammatory and autoimmune diseases such as asthma and type 1 diabetes increased in parallel with CS in these countries. Our aim was to investigate the expression level of miRNAs associated with inflammatory response and autoimmune diseases in colostrum samples and contribute to elucidating the role of CS in the pathogenesis of immune system–related diseases. Method of study: Colostrum samples were taken from voluntary mothers who had 40 normal and 50 cesarean births. miRNAs were extracted from colostrums and detected to miRNA expression profiling (eighty-four miRNAs) by quantitative real-time PCR with the Fluidigm integrated microfluidic circuit technology. Results: There was a statistically significant change in the expression levels of 17 miRNAs in the colostrums of mothers who had normal and cesarean delivery (p <.05), and all of miRNAs were upregulated in the colostrums of mothers who have had cesarean delivery. Conclusion: Our best knowledge is that the study we conducted was the first to investigate the effect of delivery method (CS or normal) on the miRNA profile of colostrum. Cesarean delivery is a potential risk factor for inflammatory and immune system–related diseases in children due to dysregulation in miRNA expression.
Yazarlar (4)
1
Fatma Humeyra Yerlikaya
2
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
3
Huseyin Altunhan
4
Merve Ilhan
Anahtar Kelimeler
autoimmune disease
Cesarean section
inflammation
miRNA
normal birth
Kurumlar
Hitit University
Corum Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
American Journal of Reproductive Immunology
Q2
SJR Skoru0,722
H-Index123
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Obstetrics and Gynecology (Q2)
Reproductive Medicine (Q2)
Immunology (Q3)
Immunology and Allergy (Q3)
Metrikler
4
Atıf
4
Yazar
5
Anahtar Kelime