Scopus
YÖKSİS Eşleşti
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease
Amino Acids · Haziran 2022
YÖKSİS Kayıtları
Elevated serum levels of kynurenine pathway metabolites in patients with Behcet disease
AMINO ACIDS · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease
Amino Acids · 2022 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease
Amino Acids · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease
Amino Acids · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease
Amino Acids · 2022 SCI-Expanded
PROFESÖR FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Makale Bilgileri
DergiAmino Acids
Yayın TarihiHaziran 2022
Cilt / Sayfa54 · 877-887
Scopus ID2-s2.0-85130525099
Özet
Behçet disease (BD) is an inflammatory, multisystemic vasculitis of unknown etiopathogenesis. However, innate and adaptive immune system involvement and immune-mediated networks play a vital role in the inflammatory cascade. Indoleamine 2,3-dioxygenase 1 (IDO1) is activated in chronic inflammatory states and catalyzes the first and rate-limiting step of tryptophan (TRP) metabolism along the kynurenine pathway (KP). The study aimed to measure KP metabolites levels in patients with BD and investigate the relationship between disease activity and clinical findings with these metabolites. The study included 120 patients with BD and 120 healthy volunteers. Serum TRP, kynurenine (KYN), kynurenic acid (KYNA), 3-hydroxyanthranilic acid (3HAA), 3-hydroxykynurenine (3HK), and quinolinic acid (QUIN) levels were measured with the tandem mass spectrometric method. Demographic data, clinical manifestations, and disease activity score (BDCAF) were recorded. Serum KYN, KYNA, 3HK, 3HAA, QUIN levels, and KYN/TRP ratio were higher (p < 0.05) in patients with BD compared to the control group, while TRP levels were lower (p < 0.05). KYN/TRP ratio and QUIN levels were significantly higher in the presence of neuro-Behçet, while serum KYN levels were significantly higher in the presence of arthritis (p < 0.05). In addition, serum QUIN levels were significantly higher in the presence of thrombosis (p < 0.05). BDCAF score positively correlated with KYN/TRP ratio. Our findings showed that serum KP metabolite levels were elevated in patients with BD, and there is a relationship between these metabolites with disease activity, clinical findings, and inflammatory burden.
Yazarlar (8)
1
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
2
Dilek Tezcan
ORCID: 0000-0002-8295-9770
3
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
4
Abdullah Sivrikaya
5
Menekse Kuzu
ORCID: 0000-0002-7076-1695
6
Fatma Humeyra Yerlikaya
7
Sema Yılmaz
ORCID: 0000-0003-4277-3880
8
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Behçet disease
Immune regulation
Inflammation
Kynurenine pathway
Kurumlar
Biruni Üniversitesi
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
4
Atıf
8
Yazar
4
Anahtar Kelime